{"id":"W2151935021","doi":"10.1242/jcs.117374","title":"Stromal Cell-Derived Factor 2 Like-1 (SDF2L1) Associates with the Endoplasmic Reticulum-Associated Degradation (ERAD) Machinery and Retards the Degradation of Mutant Proinsulin in Pancreatic β-Cells","year":2013,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; St. Jude Children's Research Hospital","keywords":"Endoplasmic-reticulum-associated protein degradation; Proinsulin; Endoplasmic reticulum; Biology; Unfolded protein response; Cell biology; Insulinoma; Immunoprecipitation; Cell culture; Endocrinology; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001227525,0.0003369623,0.0001886094,0.0001752792,0.0001291972,0.0003043715,0.000111827,0.0001627138,0.000853168],"category_scores_gemma":[0.0000806294,0.0001416428,0.0001941673,0.0001779732,0.0001430301,0.0001454094,0.000175801,0.0003634269,0.0003217189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003119745,"about_ca_system_score_gemma":0.0001571766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004205081,"about_ca_topic_score_gemma":0.000648309,"domain_scores_codex":[0.9999146,0.00001620512,0.000007568779,0.000020901,0.00001963492,0.00002111497],"domain_scores_gemma":[0.9999031,0.00001080645,0.00003287467,0.000007937128,0.000009440811,0.00003580938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000919333,0.00001719915,0.0004063736,0.00002492108,0.000003682716,0.00004620996,0.000006442106,0.00004633184,0.9984799,0.00003856239,0.00006784092,0.0007706244],"study_design_scores_gemma":[0.00002345987,0.0002129521,0.007354963,0.000006385947,0.00001109265,0.0005000142,0.00002905805,0.001056417,0.9856405,0.00003226615,0.00512857,0.000004314178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927699,0.003134553,0.002510223,0.0001684764,0.00003236289,0.00001362524,0.0006965656,0.00008645757,0.0005878941],"genre_scores_gemma":[0.9929012,0.001322952,0.00178859,0.00009278468,0.00001219773,0.0000196172,0.001316367,0.000021423,0.002524977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000853168,"threshold_uncertainty_score":0.002854168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004486585467344615,"score_gpt":0.1990813399189096,"score_spread":0.1945947544515649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}