{"id":"W2151952542","doi":"10.1002/cmdc.201200129","title":"Identification of a 17β‐Hydroxysteroid Dehydrogenase Type 10 Steroidal Inhibitor: A Tool to Investigate the Role of Type 10 in Alzheimer’s Disease and Prostate Cancer","year":2012,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Androsterone; Prostate cancer; Hydroxysteroid dehydrogenase; Disease; Dehydrogenase; Hydroxysteroid Dehydrogenases; Identification (biology); Cancer; Computational biology; Cancer research; NAD+ kinase; Enzyme; Biochemistry; Bioinformatics; Chemistry; Medicine; Biology; Internal medicine; Hormone; Steroid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004918388,0.000566421,0.0004973576,0.000637122,0.0002536415,0.0005335176,0.0004375479,0.0005810327,0.004607083],"category_scores_gemma":[0.0002760142,0.0003343697,0.0005158908,0.0003351794,0.0003041612,0.0005035194,0.0001804225,0.0008317675,0.001914823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002946069,"about_ca_system_score_gemma":0.0005202673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005578136,"about_ca_topic_score_gemma":0.001284634,"domain_scores_codex":[0.9998759,0.00002704033,0.000008121698,0.00002153659,0.00004137472,0.00002606487],"domain_scores_gemma":[0.9998286,0.0000314144,0.00002557256,0.0000206689,0.0000388815,0.00005488795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005182349,0.0002248697,0.0007705685,0.0002184948,0.00003570504,0.0002375872,0.00003363648,0.0001373228,0.9664041,0.0008418115,0.00115226,0.02942533],"study_design_scores_gemma":[0.0001518039,0.002639472,0.004824844,0.00004410281,0.000123002,0.001562526,0.00005006954,0.00103241,0.9456539,0.0003151001,0.04357607,0.00002673889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7756714,0.08868596,0.08385449,0.005322774,0.001277982,0.001053632,0.004014895,0.001325379,0.03879352],"genre_scores_gemma":[0.8158904,0.05293592,0.07838867,0.001419871,0.0002628695,0.0003635592,0.004992241,0.0001656952,0.04558076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004607083,"threshold_uncertainty_score":0.01541221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02865339525237528,"score_gpt":0.2845334616606841,"score_spread":0.2558800664083088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}