{"id":"W2151981602","doi":"10.1016/j.ejca.2005.08.017","title":"Cancer therapeutics: Targeting the dark side of Myc","year":2005,"lang":"en","type":"review","venue":"European Journal of Cancer","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":168,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Cancer research; Carcinogenesis; Transcription factor; Regulator; Cancer; Proto-Oncogene Proteins c-myc; Biology; Function (biology); Cell growth; Drug development; Gene; Computational biology; Cell biology; Drug; Genetics; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007549357,0.001134832,0.001678891,0.001539571,0.0003766695,0.001104216,0.001164437,0.001618313,0.002445494],"category_scores_gemma":[0.0004839374,0.0003254622,0.0004162843,0.001284892,0.0008693032,0.001374136,0.0006739509,0.003380913,0.001910053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009482504,"about_ca_system_score_gemma":0.0006008166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006344368,"about_ca_topic_score_gemma":0.001707735,"domain_scores_codex":[0.9998263,0.00002904303,0.00001591649,0.00003209612,0.00007136969,0.00002529017],"domain_scores_gemma":[0.9997779,0.0001084817,0.00002283126,0.00001064282,0.00005115284,0.00002902236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000175782,0.0001321973,0.0001540022,0.004305315,0.00007271145,0.000385832,0.00005178544,0.0007760935,0.00899739,0.01039987,0.0569841,0.917565],"study_design_scores_gemma":[0.00007658677,0.0001388431,0.0003980295,0.0005717289,0.00006296816,0.001628426,0.00002632771,0.0001988871,0.002914862,0.003296071,0.9906681,0.00001915365],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004199614,0.9939271,0.001147722,0.001131867,0.0009608861,0.00001491437,0.00002372051,0.00003768375,0.002336203],"genre_scores_gemma":[0.002853726,0.9914704,0.001018038,0.001106778,0.0005119877,0.0000297413,0.00005890552,0.000006385307,0.00294396],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002445494,"threshold_uncertainty_score":0.008180976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0326430702517467,"score_gpt":0.3284132160597395,"score_spread":0.2957701458079928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}