{"id":"W2152005973","doi":"10.1136/gutjnl-2013-306567","title":"Role of tumour molecular and pathology features to estimate colorectal cancer risk for first-degree relatives","year":2014,"lang":"en","type":"article","venue":"Gut","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Cancer Care Ontario; Mount Sinai Hospital","funders":"National Cancer Institute","keywords":"Lynch syndrome; First-degree relatives; Medicine; Colorectal cancer; Proband; Internal medicine; Microsatellite instability; Oncology; Cancer; DNA mismatch repair; Family history; Pathology; Genetics; Mutation; Biology; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001410658,0.0001281253,0.0002891049,0.00006331385,0.00004853583,0.000005045958,0.00006510413,0.0001027109,0.00002918104],"category_scores_gemma":[0.0005084228,0.0001077701,0.00005512126,0.00007641256,0.00009214081,0.00001483372,0.00005660664,0.0001169399,0.000003511733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003798259,"about_ca_system_score_gemma":0.0000437835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000115877,"about_ca_topic_score_gemma":0.0002937051,"domain_scores_codex":[0.9992341,0.00003744705,0.0001512422,0.0002537902,0.0001170224,0.0002063443],"domain_scores_gemma":[0.9994128,0.0001581729,0.00008380354,0.0001390514,0.00009803464,0.0001081533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00107047,0.00004955728,0.09902254,0.0001758186,0.00009442891,0.000007276479,0.001893086,0.0005456448,0.8740168,0.0004534923,0.001051412,0.02161954],"study_design_scores_gemma":[0.001352628,0.001545953,0.7753952,0.00007694765,0.0001408489,0.00003293908,0.00006124593,0.0007385265,0.2164429,0.002308573,0.001764997,0.0001392748],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954168,0.001358926,0.0007114722,0.0005435998,0.0001400196,0.0005650607,0.00005249872,0.00002518551,0.00118645],"genre_scores_gemma":[0.9901332,0.00003541401,0.009336085,0.0001288632,0.00006461087,0.0001665732,0.000004803665,0.00002449541,0.0001059753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6763726,"threshold_uncertainty_score":0.4394737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01062860928029272,"score_gpt":0.2938166239189648,"score_spread":0.2831880146386722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}