{"id":"W2152041993","doi":"10.1095/biolreprod.113.109066","title":"Stability of DNA Methylation Patterns in Mouse Spermatogonia Under Conditions of MTHFR Deficiency and Methionine Supplementation1","year":2013,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University; Royal Victoria Regional Health Centre; McGill University Health Centre; Montreal Children's Hospital","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Methylenetetrahydrofolate reductase; DNA methylation; Biology; Methylation; Methionine; Internal medicine; Genetics; Molecular biology; Endocrinology; Gene; Gene expression; Allele; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004264927,0.00007148671,0.0001467219,0.00008673743,0.00002054912,0.000001920957,0.00004395886,0.00009915968,0.00006143691],"category_scores_gemma":[0.0001361035,0.00006909895,0.00003216063,0.00009058804,0.0001540416,0.000009751574,0.00003191988,0.00003697832,4.46394e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008474565,"about_ca_system_score_gemma":0.00002558654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003397334,"about_ca_topic_score_gemma":0.00008352107,"domain_scores_codex":[0.9990532,0.0001411502,0.0003949947,0.0002728012,0.00005542647,0.00008239883],"domain_scores_gemma":[0.9992626,0.00002255178,0.000243969,0.0002540968,0.000199318,0.00001746468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001106488,0.00006782066,0.1604523,0.00003790791,0.00001050033,7.527582e-9,0.00008508904,0.00006658361,0.8370026,0.0003200045,0.000003844386,0.001942253],"study_design_scores_gemma":[0.0002167965,0.0001704621,0.2351935,0.000003504691,0.000007027238,5.622594e-7,0.0002079898,0.00002055596,0.7628767,0.00121494,0.00004272141,0.00004519774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936372,0.001282188,0.004475526,0.0001735047,0.0000657159,0.0002651046,0.00006162393,0.000002730449,0.00003639335],"genre_scores_gemma":[0.9975757,0.0005931062,0.001406464,0.000003675835,0.0000235645,0.00001649642,0.000361292,0.000005181286,0.00001449649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07474124,"threshold_uncertainty_score":0.2817774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068949492954545,"score_gpt":0.2937838916779478,"score_spread":0.2730943967484024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}