{"id":"W2152043199","doi":"10.1136/gut.2005.066092","title":"Family history and molecular features of children, adolescents, and young adults with colorectal carcinoma","year":2005,"lang":"en","type":"article","venue":"Gut","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; SickKids Foundation","funders":"","keywords":"MLH1; MSH2; Microsatellite instability; Medicine; Germline mutation; Colorectal cancer; Lynch syndrome; PMS2; Proband; Cancer; Internal medicine; DNA mismatch repair; Oncology; Genetics; Mutation; Biology; Microsatellite; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003648061,0.0001308822,0.000205223,0.00005916371,0.00001800512,0.000003356213,0.00004260179,0.00007403045,0.00001413597],"category_scores_gemma":[0.00001767467,0.0001071341,0.00002410493,0.00004565556,0.0001811258,0.00002388488,0.00003590338,0.0001352624,0.000001273906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001136964,"about_ca_system_score_gemma":0.00008202383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000261797,"about_ca_topic_score_gemma":0.0001249418,"domain_scores_codex":[0.9992844,0.00001615124,0.0001149856,0.0002326117,0.0001987853,0.0001530217],"domain_scores_gemma":[0.9996349,0.000006735271,0.00005175362,0.000142534,0.0000603753,0.000103764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001290565,0.00007716605,0.9102209,0.0001579658,0.00005372199,0.00002504871,0.00109577,0.000002217218,0.07482475,0.0000159592,0.002344392,0.009891598],"study_design_scores_gemma":[0.001979828,0.0006604827,0.983251,0.0001611727,0.00007626987,0.000218019,0.00006422339,0.00001913,0.01310473,0.000001816877,0.0003506923,0.0001126433],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835874,0.01422619,0.000007576106,0.00007206569,0.00008390011,0.0003351321,0.000007837628,0.00001957173,0.001660301],"genre_scores_gemma":[0.9983993,0.0001063729,0.0009852966,0.0002887119,0.00006396088,0.000009690498,0.000007047723,0.00002035309,0.0001192195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07303014,"threshold_uncertainty_score":0.4368801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004971491800887853,"score_gpt":0.2008179029118753,"score_spread":0.1958464111109875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}