{"id":"W2152044952","doi":"10.1128/jvi.00944-14","title":"Novel Roles of Cytoplasmic ICP0: Proteasome-Independent Functions of the RING Finger Are Required To Block Interferon-Stimulated Gene Production but Not To Promote Viral Replication","year":2014,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre","funders":"Canadian Institutes of Health Research","keywords":"Biology; RING finger domain; Ubiquitin ligase; Ring finger; Lytic cycle; Viral replication; Cytoplasm; Proteasome; Cell biology; Transcription factor; IRF3; Herpes simplex virus; Interferon; Zinc finger; Ubiquitin; Virology; Gene; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002289756,0.0006291026,0.0003369279,0.0002867491,0.0002078066,0.0005256174,0.0004297001,0.0003071964,0.0008847922],"category_scores_gemma":[0.0001719327,0.0001557483,0.0003102376,0.0001396278,0.0006124445,0.0003936062,0.000324009,0.000744744,0.0003008755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005377416,"about_ca_system_score_gemma":0.0003543338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002801602,"about_ca_topic_score_gemma":0.0003274703,"domain_scores_codex":[0.9998084,0.00003011006,0.00002002446,0.0000452266,0.00004804962,0.00004821923],"domain_scores_gemma":[0.9998395,0.00002906936,0.00004221837,0.00002933526,0.00001757002,0.00004235468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008040526,0.00001825722,0.00007231331,0.00002646078,0.000002356728,0.00007693125,0.000005866587,0.00004453573,0.9982188,0.0003243251,0.00002414123,0.001105423],"study_design_scores_gemma":[0.00002325962,0.0001685113,0.002130521,0.000004270943,0.00001548652,0.0007045864,0.00001521219,0.00097901,0.9938974,0.0001519892,0.001903714,0.00000610036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775367,0.006239359,0.01096346,0.0001763512,0.00006257057,0.00004396163,0.0004013629,0.0003751839,0.00420105],"genre_scores_gemma":[0.9928746,0.001139678,0.003919569,0.00003811578,0.00002519436,0.00003328168,0.000310832,0.00004862504,0.001609992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008847922,"threshold_uncertainty_score":0.003901601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02227277037541876,"score_gpt":0.2872408023687225,"score_spread":0.2649680319933037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}