{"id":"W2152045008","doi":"10.1111/jvp.12208","title":"Pharmacokinetics and distribution of voriconazole in body fluids of dogs after repeated oral dosing","year":2015,"lang":"en","type":"article","venue":"Journal of Veterinary Pharmacology and Therapeutics","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"North Carolina State University; Pfizer","keywords":"Pharmacokinetics; Dosing; Voriconazole; Synovial fluid; Cerebrospinal fluid; Pharmacology; Distribution (mathematics); Plasma concentration; Chemistry; Volume of distribution; Oral administration; Medicine; Anesthesia; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002630526,0.0001499396,0.000419977,0.0002640248,0.0001704008,0.0004295674,0.00009127527,0.0002626955,0.0003964157],"category_scores_gemma":[0.0006539068,0.0001259814,0.0001300499,0.0001626475,0.000356029,0.0004054319,0.0001003973,0.0003494548,0.0001310835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002706407,"about_ca_system_score_gemma":0.0002353128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006338995,"about_ca_topic_score_gemma":0.0008776431,"domain_scores_codex":[0.9998121,0.0000400179,0.0000123521,0.00004234055,0.0000708376,0.00002239062],"domain_scores_gemma":[0.9997427,0.00006401695,0.00009180113,0.00001692135,0.0000507252,0.00003379956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005544061,0.0004873496,0.0471598,0.0002117668,0.00008501395,0.0006225579,0.0009461913,0.001194395,0.8853123,0.000150722,0.0003420594,0.05794367],"study_design_scores_gemma":[0.0002702472,0.05424262,0.4602051,0.00004909019,0.0003168887,0.004016376,0.001242469,0.008145131,0.4628658,0.0003774542,0.008183844,0.00008499173],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981707,0.0007613887,0.0006649976,0.00002907874,0.000006506525,0.00001579242,0.00007995019,0.00002448708,0.0002468675],"genre_scores_gemma":[0.9982182,0.0004080925,0.0007719015,0.00002807316,0.000008579123,0.00001701549,0.0001536573,0.000005936972,0.0003885712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006338995,"threshold_uncertainty_score":0.001963615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05326683397957604,"score_gpt":0.3698966919496742,"score_spread":0.3166298579700982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}