{"id":"W2152059213","doi":"10.1586/14779072.2014.954551","title":"Alirocumab: PCSK9 inhibitor for LDL cholesterol reduction","year":2014,"lang":"en","type":"review","venue":"Expert Review of Cardiovascular Therapy","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"","keywords":"PCSK9; Alirocumab; Medicine; Ezetimibe; LDL receptor; Proprotein convertase; Kexin; Familial hypercholesterolemia; Cholesterol; Evolocumab; Internal medicine; Endocrinology; Pharmacology; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003788219,0.0008040763,0.001514261,0.00233451,0.0002227005,0.0006707272,0.0008465511,0.0009143326,0.004707617],"category_scores_gemma":[0.0004138324,0.0002354077,0.0009388116,0.001493156,0.0002231098,0.0005599137,0.0004674842,0.001632504,0.002222789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000419951,"about_ca_system_score_gemma":0.0005643121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008295205,"about_ca_topic_score_gemma":0.001814338,"domain_scores_codex":[0.9998018,0.0000374946,0.00003290691,0.0000318069,0.00007713911,0.00001892673],"domain_scores_gemma":[0.9998733,0.00004826915,0.00003196231,0.000003479889,0.00003114173,0.00001189774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001914196,0.0001059965,0.0001242741,0.02386342,0.0002991439,0.0002071021,0.0000326669,0.0002068709,0.001594126,0.001194487,0.0277126,0.944468],"study_design_scores_gemma":[0.0002770943,0.0003044806,0.001768673,0.007722051,0.0006722763,0.003426465,0.00005254132,0.0001911291,0.001440274,0.001267144,0.9828435,0.00003443701],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002156043,0.9984083,0.0001080017,0.0001861091,0.0001390048,0.00001264336,0.00003087672,0.00001227577,0.0008873012],"genre_scores_gemma":[0.001515437,0.9967672,0.0002265862,0.0003043131,0.0001070849,0.00001735137,0.00007904003,0.000002348535,0.0009807139],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004707617,"threshold_uncertainty_score":0.0157485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04405893607552818,"score_gpt":0.3699339682634757,"score_spread":0.3258750321879476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}