{"id":"W2152061559","doi":"10.1038/nature12477","title":"Signatures of mutational processes in human cancer","year":2013,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10140,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of British Columbia Hospital; Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"Cancer Research UK Cambridge Institute, University of Cambridge; National Cancer Institute; Labex Immuno-Oncology; BC Cancer Agency; Medisinske fakultet, Universitetet i Oslo; Universitat de Barcelona; Háskóli Íslands; Universitetet i Oslo; University of Glasgow; Institut National de la Santé et de la Recherche Médicale; Wellcome Trust; Agence Nationale de la Recherche; Cancer Research UK; Broad Institute; University of New South Wales; Canada's Michael Smith Genome Sciences Centre; Lunds Universitet; Deutsches Krebsforschungszentrum","keywords":"Cancer; Computational biology; Human genome; Biology; Genetics; Genome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001659712,0.00009064979,0.0001775749,0.001022601,0.0001603611,0.0004252088,0.0001465578,0.0002727037,0.000942594],"category_scores_gemma":[0.0006575005,0.0001325974,0.00009494432,0.0006283182,0.0002260924,0.0002355289,0.0002192112,0.000220298,0.00016709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001948451,"about_ca_system_score_gemma":0.0001330386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003170871,"about_ca_topic_score_gemma":0.0005115707,"domain_scores_codex":[0.9998664,0.00002355002,0.000008374946,0.00002974544,0.00004853752,0.00002351326],"domain_scores_gemma":[0.9996828,0.00009387988,0.0001154894,0.0000424157,0.00003416391,0.00003120488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009850916,0.00006317625,0.1098962,0.0001415034,0.0000654758,0.000625651,0.0002481578,0.00246707,0.8130689,0.007058255,0.000760933,0.06461964],"study_design_scores_gemma":[0.00003416747,0.0003953081,0.7611486,0.00003818803,0.0001043656,0.007386921,0.0002294409,0.009098493,0.195402,0.01396602,0.01216067,0.00003584017],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911649,0.00262306,0.002900248,0.0001923243,0.00001236666,0.000007753501,0.0003638002,0.0001139782,0.002621482],"genre_scores_gemma":[0.9982756,0.0005048199,0.0005941712,0.00004412205,0.00001199782,0.000004156273,0.0001451882,0.0000127779,0.0004071371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001022601,"threshold_uncertainty_score":0.003153265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004499574583629951,"score_gpt":0.2686962727638121,"score_spread":0.2641966981801822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}