{"id":"W2152098155","doi":"10.1093/hmg/ddu334","title":"Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":240,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institutes of Health; University of New South Wales; University of Sheffield; Neuroscience Research Australia; National Institute of Neurological Disorders and Stroke; Ministerio de Ciencia e Innovación; National Center for Advancing Translational Sciences; Wellcome Trust; Canadian Institutes of Health Research; University of Dundee; National Institute on Aging; Parkinson's Disease Foundation; Parkinson's UK; National Health and Medical Research Council; Stichting Dioraphte; Vanderbilt University Medical Center; Medical Research Council; Mayo Clinic; Michael J. Fox Foundation for Parkinson's Research","keywords":"Dementia with Lewy bodies; Etiology; Biology; Dementia; Parkinson's disease; Apolipoprotein E; Glucocerebrosidase; Disease; Genetic association; Locus (genetics); Pathology; Genetics; Bioinformatics; Medicine; Single-nucleotide polymorphism; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009370788,0.0001410296,0.0002617608,0.0001676,0.00005957708,0.00001267945,0.0000710969,0.0000581248,0.00002122114],"category_scores_gemma":[0.000009473683,0.00009661457,0.00007002788,0.0001693772,0.00009948962,0.00001034234,0.00003086643,0.00005844342,0.000002122994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001075923,"about_ca_system_score_gemma":0.00001593162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004880498,"about_ca_topic_score_gemma":0.0001836375,"domain_scores_codex":[0.9991027,0.0001045709,0.0001879449,0.000260099,0.0001695809,0.0001750886],"domain_scores_gemma":[0.9994423,0.00002202793,0.00008474303,0.0003392955,0.00005289754,0.00005871806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009880137,0.0003241478,0.9311085,0.00006624548,0.001654261,0.00007242998,0.0003075723,0.0004017634,0.06208863,0.001191976,0.00001912357,0.002666567],"study_design_scores_gemma":[0.001284371,0.0007468994,0.9891008,0.00001256547,0.002791301,0.00002260124,0.00005561823,0.000508438,0.004182669,0.0009613394,0.0002411784,0.00009222171],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928746,0.001741939,0.004753572,0.00007027446,0.00000886789,0.0002369385,0.000004552445,0.000009306435,0.0002999574],"genre_scores_gemma":[0.9978011,0.0001114454,0.001788464,0.0001778725,0.00001676236,0.00003549644,0.00004417499,0.00001410212,0.00001064487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05799231,"threshold_uncertainty_score":0.3939828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01013183829281957,"score_gpt":0.2504808202322188,"score_spread":0.2403489819393993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}