{"id":"W2152098155","doi":"10.1093/hmg/ddu334","title":"Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":240,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institutes of Health; University of New South Wales; University of Sheffield; Neuroscience Research Australia; National Institute of Neurological Disorders and Stroke; Ministerio de Ciencia e Innovación; National Center for Advancing Translational Sciences; Wellcome Trust; Canadian Institutes of Health Research; University of Dundee; National Institute on Aging; Parkinson's Disease Foundation; Parkinson's UK; National Health and Medical Research Council; Stichting Dioraphte; Vanderbilt University Medical Center; Medical Research Council; Mayo Clinic; Michael J. Fox Foundation for Parkinson's Research","keywords":"Dementia with Lewy bodies; Etiology; Biology; Dementia; Parkinson's disease; Apolipoprotein E; Glucocerebrosidase; Disease; Genetic association; Locus (genetics); Pathology; Genetics; Bioinformatics; Medicine; Single-nucleotide polymorphism; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007447487,0.0003828162,0.0003658955,0.001195899,0.0003936112,0.0004689405,0.0002187846,0.0003028616,0.00138562],"category_scores_gemma":[0.001224978,0.0001894696,0.0002600324,0.0005942145,0.0004786006,0.0001562704,0.0003027681,0.0002277237,0.0001386978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002191447,"about_ca_system_score_gemma":0.0002560719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003049065,"about_ca_topic_score_gemma":0.003892975,"domain_scores_codex":[0.9996643,0.000102999,0.00004599264,0.00008344098,0.00006311083,0.00004012624],"domain_scores_gemma":[0.9994506,0.0001460592,0.0002393837,0.00005561103,0.00004329571,0.0000650861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001368859,0.0001004567,0.9532604,0.00005804168,0.0002765145,0.004142707,0.0002085035,0.0002283281,0.02970712,0.0004024283,0.0001744358,0.01007225],"study_design_scores_gemma":[0.00005592326,0.0002424054,0.9813063,0.00003244836,0.000271826,0.008739594,0.0001925082,0.0006018306,0.007082262,0.0007441085,0.0007215407,0.000009248082],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987274,0.0005601358,0.0002111623,0.00005153008,0.000003671854,0.000003167556,0.00004517804,0.000005517639,0.0003921309],"genre_scores_gemma":[0.9993579,0.0001993736,0.0002138491,0.00001764149,0.000006252839,0.000001308088,0.00004897915,0.000002094255,0.0001527753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003049065,"threshold_uncertainty_score":0.006062627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01013183829281957,"score_gpt":0.2504808202322188,"score_spread":0.2403489819393993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}