{"id":"W2152114144","doi":"10.1093/toxsci/kfq377","title":"Human Prostaglandin H Synthase (hPHS)-1 and hPHS-2 in Amphetamine Analog Bioactivation, DNA Oxidation, and Cytotoxicity","year":2010,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Forensic Toxicology and Drug Analysis","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxicity; Chemistry; Chinese hamster ovary cell; Biochemistry; Meth-; Neurotoxicity; DNA damage; Isozyme; Pharmacology; Enzyme; Molecular biology; In vitro; Biology; DNA; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001781877,0.0002102567,0.0001429354,0.0002167535,0.000110484,0.0001745475,0.000114249,0.0002227614,0.0007288907],"category_scores_gemma":[0.0001399463,0.0001348415,0.0002430736,0.0002364179,0.0001355751,0.0001491604,0.0001162163,0.0002492972,0.0002277997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001759721,"about_ca_system_score_gemma":0.0001190148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004890315,"about_ca_topic_score_gemma":0.0008922584,"domain_scores_codex":[0.9998693,0.00003444835,0.00001938701,0.00002308803,0.0000322074,0.000021512],"domain_scores_gemma":[0.9999442,0.00001427016,0.00001389434,0.000008151073,0.000009115015,0.00001035244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002560991,0.0000437395,0.0007851542,0.00003885303,0.000009967965,0.00005584431,0.00001487827,0.0000907221,0.9962317,0.0000538822,0.00002596462,0.002393268],"study_design_scores_gemma":[0.00002449087,0.000689581,0.01199354,0.000006327185,0.00002185796,0.000563828,0.00002235641,0.0004774029,0.9841964,0.00004302161,0.001956278,0.000004905064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907657,0.006015696,0.00188702,0.00006393691,0.00001919694,0.00004239026,0.0003095624,0.00002100853,0.0008753988],"genre_scores_gemma":[0.9919279,0.002788298,0.002145918,0.00003693282,0.00001665331,0.00005692501,0.0009676112,0.000003518319,0.002056236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007288907,"threshold_uncertainty_score":0.002438426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08255847527404334,"score_gpt":0.4137968161648516,"score_spread":0.3312383408908083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}