{"id":"W2152128148","doi":"10.1515/bc.2010.051","title":"Detection and in-cell selectivity profiling of the full-length West Nile virus NS2B/NS3 serine protease using membrane-anchored fluorescent substrates","year":2010,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Centers for Disease Control and Prevention","keywords":"NS3; Protease; Serine protease; Biology; Linker; Chemistry; Biochemistry; Proteases; Cell biology; Cell membrane; Endoplasmic reticulum; Cell; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002584195,0.000386635,0.0003373637,0.0001752935,0.0001404549,0.0003858912,0.0002265372,0.0003907528,0.0004079095],"category_scores_gemma":[0.0001583186,0.0001366153,0.0001828644,0.0001674519,0.0001605287,0.0002291525,0.0001946059,0.000419901,0.00026074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002566621,"about_ca_system_score_gemma":0.0001257405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005511803,"about_ca_topic_score_gemma":0.0009929097,"domain_scores_codex":[0.999782,0.00004578164,0.00001664785,0.00004719123,0.00007234177,0.00003593305],"domain_scores_gemma":[0.999895,0.00003478892,0.0000193124,0.00001410906,0.00002381854,0.000012937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001685698,0.000008698076,0.00009386382,0.00001122314,0.000001617509,0.00001011686,0.000007140616,0.00003045744,0.9993298,0.00001388787,0.000009803518,0.0004665056],"study_design_scores_gemma":[0.000001478309,0.00004319382,0.0008465449,5.804398e-7,0.000004206943,0.00005351885,0.00001113421,0.0008721852,0.9977978,0.000007247044,0.00036048,0.00000173247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9607781,0.00142839,0.03549691,0.00007651659,0.0000215349,0.00006950337,0.0005588983,0.0001323359,0.001437912],"genre_scores_gemma":[0.9638076,0.001743087,0.03138869,0.00007038077,0.00001234332,0.0001105668,0.0007262324,0.00004040964,0.002100601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005511803,"threshold_uncertainty_score":0.001862168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01366525791243017,"score_gpt":0.2404757191975551,"score_spread":0.226810461285125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}