{"id":"W2152158810","doi":"10.1111/j.1365-2958.2011.07769.x","title":"Stage‐specific requirement for Isa1 and Isa2 proteins in the mitochondrion of <i>Trypanosoma brucei</i> and heterologous rescue by human and <i>Blastocystis</i> orthologues","year":2011,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Metalloenzymes and iron-sulfur proteins","field":"Energy","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Grantová Agentura České Republiky; Canadian Institute for Advanced Research","keywords":"Biology; Aconitase; Fumarase; Trypanosoma brucei; Mitochondrion; Cell biology; Alternative oxidase; Organelle; Blastocystis; Heterologous; Biochemistry; Gene; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001975784,0.0002628322,0.0004099302,0.00007454026,0.0001123331,0.00002172554,0.0002098667,0.0002415313,0.00002186556],"category_scores_gemma":[0.00002395991,0.0001994832,0.00006214616,0.00007436424,0.0004660305,0.00005658539,0.0001577598,0.0001682786,0.000001323022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001450963,"about_ca_system_score_gemma":0.000009958991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006250789,"about_ca_topic_score_gemma":0.0006540204,"domain_scores_codex":[0.9982205,0.0003411541,0.000450347,0.0005486055,0.00005527568,0.0003841073],"domain_scores_gemma":[0.999324,0.00004119825,0.0001548058,0.0003904041,0.00003785788,0.00005176135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001571453,0.00009803205,0.0002447161,0.00006727508,0.00003544707,0.0000237642,0.0007579915,0.000002051224,0.9923433,0.00504363,0.0004375246,0.0007891117],"study_design_scores_gemma":[0.002656946,0.002493695,0.002521809,0.00005385328,0.00004244456,0.0002145817,0.0002569659,0.000006708477,0.9050577,0.001406006,0.08489972,0.0003895367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911146,0.005698123,0.00121965,0.0001723725,0.00006331757,0.001311076,0.00009704928,0.00001946157,0.0003043712],"genre_scores_gemma":[0.9962726,0.0002229954,0.002368319,0.0006465882,0.00002126758,0.0002075551,0.0001048561,0.0000323293,0.0001234843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08728557,"threshold_uncertainty_score":0.813469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02158698047101884,"score_gpt":0.227957846305051,"score_spread":0.2063708658340322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}