{"id":"W2152161503","doi":"10.1345/aph.1k615","title":"Induction Effects of Ritonavir: Implications for Drug Interactions","year":2008,"lang":"en","type":"article","venue":"Annals of Pharmacotherapy","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Capital District Health Authority","funders":"","keywords":"Ritonavir; Darunavir; CYP3A; Pharmacology; Medicine; Drug interaction; Drug; Cobicistat; Drug metabolism; Cytochrome P450; Internal medicine; Metabolism; Immunology; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003989849,0.0002221928,0.0003902069,0.0002349566,0.0002564982,0.000003618682,0.0003158197,0.00009062611,0.0002988788],"category_scores_gemma":[0.00004832993,0.0002254658,0.000313976,0.0003128466,0.0002596561,0.0001676175,0.00002967569,0.0003251373,0.0000118953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000111796,"about_ca_system_score_gemma":0.000100827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003267985,"about_ca_topic_score_gemma":0.000002497754,"domain_scores_codex":[0.9984403,0.0002433775,0.0005647752,0.0002751915,0.0001230697,0.0003533352],"domain_scores_gemma":[0.9980562,0.0006858559,0.0003904814,0.0002199273,0.0004503395,0.0001971725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003755863,0.0008737945,0.002400349,0.0001166607,0.0004066908,0.00000120717,0.001098675,0.0001670449,0.9108372,0.001111551,0.031285,0.05132623],"study_design_scores_gemma":[0.001799801,0.00006307504,0.00391021,0.00001142089,0.00009907938,0.00001174827,0.00001677736,0.0002383582,0.7411565,0.001361933,0.2511799,0.000151218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862517,0.005205837,0.0007613228,0.003304377,0.002105719,0.0009666019,0.0002851505,0.00006061102,0.001058727],"genre_scores_gemma":[0.9802414,0.01452923,0.0006583859,0.002908591,0.0005262489,0.0002692746,0.0000315394,0.0000411295,0.0007941777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2198949,"threshold_uncertainty_score":0.9194227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2931177938528937,"score_gpt":0.5361824232976135,"score_spread":0.2430646294447198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}