{"id":"W2152162065","doi":"10.1016/s1470-2045(15)00169-2","title":"Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a prospective clinical trial and validation in a population-based registry","year":2015,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":613,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"BC Cancer Agency; Canadian Institutes of Health Research; H. Lundbeck A/S; University of British Columbia; Celgene; Terry Fox Research Institute; Genome British Columbia; Dr. Mildred Scheel Stiftung für Krebsforschung; Michael Smith Health Research BC; Amgen; Alfred Benzon Foundation; Genome Canada; Deutsche Krebshilfe","keywords":"Medicine; Rituximab; Follicular lymphoma; Internal medicine; Oncology; Population; Vincristine; Prednisone; International Prognostic Index; Cyclophosphamide; Lymphoma; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001188848,0.00008568457,0.0006481889,0.0001824429,0.00003006636,0.000004771004,0.00004457736,0.0001113791,9.22583e-7],"category_scores_gemma":[0.003498874,0.00006149389,0.0001163247,0.0004533962,0.00005641935,0.00003736616,0.000006127255,0.00004316618,6.609819e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000583307,"about_ca_system_score_gemma":0.0001905223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006432296,"about_ca_topic_score_gemma":0.001356685,"domain_scores_codex":[0.9987875,0.0001865161,0.0006036807,0.0002106756,0.0001096529,0.0001020086],"domain_scores_gemma":[0.9976546,0.001161558,0.0005777135,0.0001969021,0.0003842138,0.00002503481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02096594,0.002214375,0.9666291,0.00002096135,0.0003464284,3.207836e-7,0.0008214616,0.0003086933,0.000035954,0.0001955942,0.000009953661,0.008451179],"study_design_scores_gemma":[0.09570821,0.003712841,0.8830721,0.00004609155,0.0008765151,3.225211e-7,0.0000842412,0.01441507,0.0006706993,0.001357782,0.00001134688,0.00004481753],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924354,0.00006913285,0.003359081,0.0005894536,0.00006087209,0.003365084,0.00009761544,0.000007040304,0.00001633028],"genre_scores_gemma":[0.9898498,0.000082238,0.008038856,0.00003107516,0.00007116512,0.001248667,0.0006683157,0.000007678799,0.000002205474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08355708,"threshold_uncertainty_score":0.4188732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06967241767753558,"score_gpt":0.3970410134681473,"score_spread":0.3273685957906117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}