{"id":"W2152162065","doi":"10.1016/s1470-2045(15)00169-2","title":"Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a prospective clinical trial and validation in a population-based registry","year":2015,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":613,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"BC Cancer Agency; Canadian Institutes of Health Research; H. Lundbeck A/S; University of British Columbia; Celgene; Terry Fox Research Institute; Genome British Columbia; Dr. Mildred Scheel Stiftung für Krebsforschung; Michael Smith Health Research BC; Amgen; Alfred Benzon Foundation; Genome Canada; Deutsche Krebshilfe","keywords":"Medicine; Rituximab; Follicular lymphoma; Internal medicine; Oncology; Population; Vincristine; Prednisone; International Prognostic Index; Cyclophosphamide; Lymphoma; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005691822,0.0004638568,0.0009022412,0.0008982127,0.000558694,0.001694717,0.001005251,0.0008495423,0.001399105],"category_scores_gemma":[0.01230731,0.0005403293,0.001483033,0.002519968,0.0009721678,0.001229723,0.0007704433,0.0009518806,0.0002736413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006678251,"about_ca_system_score_gemma":0.000707319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001623562,"about_ca_topic_score_gemma":0.002005088,"domain_scores_codex":[0.9934929,0.003654145,0.0005925043,0.001236517,0.0005501499,0.0004737691],"domain_scores_gemma":[0.9869174,0.004310552,0.004823572,0.002437904,0.0008522806,0.0006584711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005171607,0.0000943513,0.9907755,0.00002933878,0.001082284,0.00007398687,0.00008642949,0.0001362647,0.0005346678,0.00006483105,0.0001275103,0.001823111],"study_design_scores_gemma":[0.0006016202,0.001405776,0.9941434,0.000019394,0.001636426,0.0003473735,0.0001613426,0.0005528395,0.0005476864,0.0001212142,0.0004451788,0.00001783417],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984667,0.0005477114,0.0002085387,0.00004766078,0.00001126176,0.00003043638,0.0004358487,0.000006090249,0.000245632],"genre_scores_gemma":[0.9992009,0.00008339729,0.0001572839,0.00002522364,0.00001449934,0.000019859,0.0004403875,0.000004681581,0.00005376734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005691822,"threshold_uncertainty_score":0.0301016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06967241767753558,"score_gpt":0.3970410134681473,"score_spread":0.3273685957906117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}