{"id":"W2152163646","doi":"10.1042/bj20030884","title":"Proline residues in transmembrane segment IV are critical for activity, expression and targeting of the Na+/H+ exchanger isoform 1","year":2004,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"Canadian Institutes of Health Research; Brock University; Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada","keywords":"Sodium–hydrogen antiporter; Transmembrane domain; Gene isoform; Mutant; Transmembrane protein; Intracellular pH; Proline; Wild type; Biochemistry; Chemistry; Cell biology; Intracellular; Mutation; Molecular biology; Biology; Amino acid; Sodium; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008762107,0.0003052238,0.0002149375,0.00008616803,0.0001255576,0.0002386657,0.0001282418,0.0002683081,0.0008484526],"category_scores_gemma":[0.0001787152,0.0001096172,0.0002075436,0.00008488337,0.0001510215,0.0001434826,0.0001396413,0.0003709207,0.0004411339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001803935,"about_ca_system_score_gemma":0.0001669341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000443371,"about_ca_topic_score_gemma":0.0003957753,"domain_scores_codex":[0.9998906,0.00002095652,0.0000172241,0.00002589795,0.00002309777,0.00002210825],"domain_scores_gemma":[0.9997707,0.00002569825,0.0001094587,0.00001074793,0.00002184952,0.00006161757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001234278,0.000004928751,0.0003747004,0.00002404278,0.000003259436,0.0001239968,0.000006174737,0.00004767149,0.9987854,0.0000335719,0.00001799147,0.0004547783],"study_design_scores_gemma":[0.00004420164,0.0003265214,0.0381126,0.00001507553,0.00004610204,0.002499688,0.00007617153,0.0010337,0.9543597,0.0001160014,0.00335914,0.000011033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973833,0.0006412447,0.001316799,0.00006702617,0.00002108457,0.00001008279,0.0001741342,0.0000240417,0.000362315],"genre_scores_gemma":[0.9970776,0.0004094072,0.001466313,0.00004138693,0.00001195079,0.0000100282,0.0003659079,0.00001415394,0.0006032637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008484526,"threshold_uncertainty_score":0.002838314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01186821246300212,"score_gpt":0.2581638345417439,"score_spread":0.2462956220787417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}