{"id":"W2152163646","doi":"10.1042/bj20030884","title":"Proline residues in transmembrane segment IV are critical for activity, expression and targeting of the Na+/H+ exchanger isoform 1","year":2004,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"Canadian Institutes of Health Research; Brock University; Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada","keywords":"Sodium–hydrogen antiporter; Transmembrane domain; Gene isoform; Mutant; Transmembrane protein; Intracellular pH; Proline; Wild type; Biochemistry; Chemistry; Cell biology; Intracellular; Mutation; Molecular biology; Biology; Amino acid; Sodium; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001702406,0.00009037556,0.0001125157,0.00002467999,0.00006626495,0.000009588336,0.00008405268,0.0001358019,0.000005054219],"category_scores_gemma":[0.00006115927,0.00006192739,0.00008223073,0.00004135925,0.00008009229,0.000006475801,0.00002258457,0.000108341,5.956139e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001519279,"about_ca_system_score_gemma":0.00003545867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001920437,"about_ca_topic_score_gemma":0.000003730665,"domain_scores_codex":[0.9993628,0.0000169495,0.0001911959,0.0001402273,0.0001271961,0.0001616626],"domain_scores_gemma":[0.9997165,0.00001048928,0.00007433714,0.00007352294,0.00006834444,0.00005681246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002862691,0.00008898007,0.001206018,0.00008137608,0.000006004068,0.000001085025,0.00007916086,0.00002547259,0.9977923,0.000009898252,0.0001068031,0.0003166436],"study_design_scores_gemma":[0.001040232,0.00009289942,0.008787779,0.0001622749,0.000009448059,0.00002395622,0.00007080895,0.00002402595,0.9891949,0.000363405,0.0001497727,0.00008045159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942632,0.0007587456,0.003521118,0.001205488,0.00007755955,0.0001497892,0.00001171173,0.000002279522,0.00001009747],"genre_scores_gemma":[0.9985943,0.0001105032,0.0009338736,0.00004864274,0.0002625653,0.00001066566,0.00001279804,0.00000989629,0.00001668548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008597342,"threshold_uncertainty_score":0.2525326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01186821246300212,"score_gpt":0.2581638345417439,"score_spread":0.2462956220787417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}