{"id":"W2152175400","doi":"10.1073/pnas.0913021108","title":"Decreased stability and increased formation of soluble aggregates by immature superoxide dismutase do not account for disease severity in ALS","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"SOD1; Protein aggregation; Chemistry; Superoxide dismutase; Neurodegeneration; Mutant; Biophysics; Amyotrophic lateral sclerosis; Mutation; Biochemistry; Protein folding; Denaturation (fissile materials); Biology; Antioxidant; Disease; Gene; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003469225,0.0005028692,0.0005243002,0.0005578679,0.0001913716,0.0003879442,0.0002907787,0.0004557171,0.0006997585],"category_scores_gemma":[0.0006485243,0.0001975311,0.0003112541,0.0002752419,0.0004231505,0.0003281685,0.000275118,0.0007955836,0.0002252546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001757861,"about_ca_system_score_gemma":0.000136572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003223965,"about_ca_topic_score_gemma":0.0002342651,"domain_scores_codex":[0.9995731,0.00005544076,0.00008215615,0.0001247398,0.0001361525,0.00002849831],"domain_scores_gemma":[0.9993433,0.00006996081,0.000292754,0.00008214142,0.00008744268,0.0001244028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002740867,0.00003434509,0.01133461,0.00003529017,0.00005320847,0.0001177946,0.00004053574,0.0001475536,0.9860773,0.00003554173,0.00002827498,0.001821413],"study_design_scores_gemma":[0.00002562,0.0009898797,0.3225113,0.00002181041,0.0002430478,0.003002731,0.0001186916,0.003922787,0.6672428,0.0004776932,0.001415636,0.00002806482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962159,0.0009586467,0.002098144,0.00003614601,0.00001079459,0.00001781639,0.0003450727,0.00005580552,0.0002616736],"genre_scores_gemma":[0.9981014,0.0001919005,0.001053231,0.00002066644,0.000005041023,0.000009604702,0.0003657341,0.00002032815,0.0002321286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006997585,"threshold_uncertainty_score":0.002340913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06574310218101301,"score_gpt":0.3156732893488346,"score_spread":0.2499301871678216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}