{"id":"W2152209571","doi":"10.1158/1078-0432.ccr-07-0823","title":"Nutritional Modulation of Antitumor Efficacy and Diarrhea Toxicity Related to Irinotecan Chemotherapy in Rats Bearing the Ward Colon Tumor","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Foundation of Canada; Natural Sciences and Engineering Research Council of Canada; Crohn's and Colitis Foundation","keywords":"Diarrhea; Irinotecan; Gastroenterology; Medicine; Glutamine; Internal medicine; Chemotherapy; Toxicity; Bolus (digestion); Loperamide; Colorectal cancer; Cancer; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002821596,0.00008253197,0.0001667988,0.00007470397,0.00008129362,0.00001577767,0.0001770532,0.000116024,0.00002346453],"category_scores_gemma":[0.0001720699,0.00006828715,0.00005223916,0.0002734512,0.0002021852,0.000003232971,0.0001174581,0.0003093005,0.000001546815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004661076,"about_ca_system_score_gemma":0.0001420387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000189468,"about_ca_topic_score_gemma":0.0004829634,"domain_scores_codex":[0.9985825,0.0001422144,0.0003855756,0.0003284418,0.0002641618,0.0002970825],"domain_scores_gemma":[0.9992518,0.0001783073,0.00005765787,0.0002363847,0.0001643625,0.0001115208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001981744,0.0002863335,0.01198759,0.00002530975,0.0000362131,0.000004660312,0.0000997265,0.00009460708,0.9585688,0.0004912025,0.0001624806,0.02626132],"study_design_scores_gemma":[0.002628259,0.00133372,0.3639942,0.00008915603,0.000005881124,0.000003812684,0.00005452257,0.0002553244,0.6210425,0.0009906996,0.009446119,0.0001558015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969847,0.000567326,0.0002083564,0.001498114,0.0001189532,0.0005013625,0.0000132229,0.00000398464,0.0001040358],"genre_scores_gemma":[0.9982815,0.0008467693,0.0001397126,0.0004031028,0.0001774156,0.00003264168,0.000009421206,0.00001542807,0.00009405829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3520066,"threshold_uncertainty_score":0.2784669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09254496655887531,"score_gpt":0.4659362927917555,"score_spread":0.3733913262328802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}