{"id":"W2152213414","doi":"10.1128/jvi.02484-10","title":"Mutations in the Glycoprotein of Vesicular Stomatitis Virus Affect Cytopathogenicity: Potential for Oncolytic Virotherapy","year":2011,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Université du Québec à Montréal","funders":"Canadian Institutes of Health Research","keywords":"Vesicular stomatitis virus; Oncolytic virus; Biology; Mutant; Virology; Virus; Glycoprotein; Interferon; Rhabdoviridae; Secretion; Wild type; Vesicular Stomatitis; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008814232,0.0001137825,0.0002500708,0.000144438,0.00004737603,0.000006970562,0.0003918155,0.0001463309,0.0000571811],"category_scores_gemma":[0.0001090022,0.0000845597,0.0001981925,0.0001312622,0.000147442,0.000006829728,0.00002562638,0.0001646832,0.000002205667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002038489,"about_ca_system_score_gemma":0.0001771838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002319829,"about_ca_topic_score_gemma":0.0002201436,"domain_scores_codex":[0.998627,0.0004176806,0.0004095105,0.0001372049,0.0001864973,0.0002220871],"domain_scores_gemma":[0.999207,0.00004996426,0.0002959978,0.0002466523,0.0001564331,0.00004400166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003893373,0.0002564426,0.0002923594,0.00001266095,0.000104626,0.00004596421,0.00030062,0.000181881,0.9903532,0.00003564101,0.00007480911,0.004448375],"study_design_scores_gemma":[0.002859763,0.01976775,0.01095285,0.00001395355,0.00004685986,0.0003276048,0.00009901144,0.0001796601,0.9638923,0.001163358,0.0005763748,0.0001204736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925423,0.0009319562,0.005711272,0.0002067695,0.0000854356,0.0004482612,0.00002563296,0.000001618718,0.00004679576],"genre_scores_gemma":[0.9979268,0.0002371284,0.001229721,0.0003443116,0.0001807395,0.00004099495,0.000006053697,0.00001961322,0.0000146067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0264609,"threshold_uncertainty_score":0.3448245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02263712905950509,"score_gpt":0.3056383845708701,"score_spread":0.283001255511365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}