{"id":"W2152250507","doi":"10.1523/jneurosci.1171-11.2011","title":"Characterization of 3,4-Methylenedioxymethamphetamine (MDMA) Enantiomers<i>In Vitro</i>and in the MPTP-Lesioned Primate:<i>R</i>-MDMA Reduces Severity of Dyskinesia, Whereas<i>S</i>-MDMA Extends Duration of ON-Time","year":2011,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"Edmond J. Safra Philanthropic Foundation; Parkinson Society Canada","keywords":"MDMA; Dyskinesia; Hallucinogen; MPTP; Primate; Psychology; Ecstasy; Pharmacology; Neuroscience; Medicine; Parkinson's disease; Internal medicine; Dopamine; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001752454,0.000371549,0.0002424394,0.0002173837,0.0002944727,0.0003154766,0.0001711014,0.0002563613,0.001004262],"category_scores_gemma":[0.0001806296,0.0001954017,0.0003773668,0.0001728578,0.0001403051,0.0001820379,0.00008566686,0.000397977,0.0007696904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000224211,"about_ca_system_score_gemma":0.0003156839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001837795,"about_ca_topic_score_gemma":0.002406094,"domain_scores_codex":[0.9998611,0.00003477984,0.00001421481,0.00002721855,0.00003754245,0.00002510843],"domain_scores_gemma":[0.999886,0.00001866972,0.00003105793,0.00001235919,0.00002808141,0.00002372718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009793471,0.00003971998,0.0001928501,0.00004851996,0.00001110692,0.00008730836,0.00001323063,0.00007848867,0.9974468,0.0000923371,0.00005120298,0.00184057],"study_design_scores_gemma":[0.00001414437,0.0005393472,0.002680467,0.000008894448,0.00003141631,0.0004886279,0.00002811253,0.0005437179,0.9900646,0.00002826871,0.005565284,0.000007113088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661262,0.01022511,0.01041998,0.0002931261,0.00009229474,0.000274932,0.003798308,0.0001134725,0.008656677],"genre_scores_gemma":[0.969759,0.007851231,0.01103526,0.0001918667,0.00007550221,0.0001355353,0.005576602,0.00006984644,0.005305229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001837795,"threshold_uncertainty_score":0.003654182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03897904274483707,"score_gpt":0.2780867400473529,"score_spread":0.2391076973025158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}