{"id":"W2152253342","doi":"10.1016/j.immuni.2011.10.016","title":"Cellular Inhibitors of Apoptosis Proteins cIAP1 and cIAP2 Are Required for Efficient Caspase-1 Activation by the Inflammasome","year":2011,"lang":"en","type":"article","venue":"Immunity","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":165,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; McGill University; Burroughs Wellcome Fund","keywords":"Inflammasome; Caspase; Cell biology; Biology; Innate immune system; Inhibitor of apoptosis; Signal transducing adaptor protein; XIAP; Caspase 1; AIM2; Inflammation; NLRC4; Effector; Caspase 8; Programmed cell death; Apoptosis; Signal transduction; Immunology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002759685,0.0001316498,0.0001300503,0.00003226903,0.0001948709,0.00001069604,0.0001727801,0.0001280876,0.000007187744],"category_scores_gemma":[0.0001485859,0.0001051071,0.0000809658,0.0000815558,0.0001550264,0.000006579994,0.0001079338,0.00008907176,9.00313e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009441187,"about_ca_system_score_gemma":0.000032763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002397301,"about_ca_topic_score_gemma":0.00001697611,"domain_scores_codex":[0.9992709,0.00008202314,0.0002239041,0.0001578348,0.0000836507,0.0001817527],"domain_scores_gemma":[0.9992545,0.00001740501,0.0001965483,0.0003811043,0.0001240896,0.00002638471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001676961,0.00009634467,0.0008749696,0.00003827936,0.00004992779,6.190994e-8,0.0006198069,0.000004248187,0.9962353,0.00003409322,0.0004203103,0.001458949],"study_design_scores_gemma":[0.0005494293,0.0002431622,0.002343191,0.00002284772,0.00002064465,5.579788e-7,0.001116884,0.00002193574,0.992313,0.00005333388,0.003181876,0.0001331048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976575,0.0004575365,0.0006743051,0.0000791944,0.00006863598,0.0006146969,0.00002714661,0.000008008222,0.0004129928],"genre_scores_gemma":[0.9993961,0.00003830868,0.00009822688,0.00004762785,0.00003567125,0.000102346,0.0001132529,0.00001741039,0.0001509922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00392228,"threshold_uncertainty_score":0.4286145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01508414161380357,"score_gpt":0.2155535945582283,"score_spread":0.2004694529444247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}