{"id":"W2152253342","doi":"10.1016/j.immuni.2011.10.016","title":"Cellular Inhibitors of Apoptosis Proteins cIAP1 and cIAP2 Are Required for Efficient Caspase-1 Activation by the Inflammasome","year":2011,"lang":"en","type":"article","venue":"Immunity","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":165,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; McGill University; Burroughs Wellcome Fund","keywords":"Inflammasome; Caspase; Cell biology; Biology; Innate immune system; Inhibitor of apoptosis; Signal transducing adaptor protein; XIAP; Caspase 1; AIM2; Inflammation; NLRC4; Effector; Caspase 8; Programmed cell death; Apoptosis; Signal transduction; Immunology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004849614,0.0006438785,0.0005485917,0.0004576942,0.0004026786,0.001352598,0.0003857053,0.0005493307,0.002519511],"category_scores_gemma":[0.0008087126,0.0003721073,0.000407549,0.0003227025,0.0004113888,0.0009384995,0.0005670416,0.001739286,0.001503483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009440059,"about_ca_system_score_gemma":0.0004356534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001962724,"about_ca_topic_score_gemma":0.0002621818,"domain_scores_codex":[0.9994093,0.00008128735,0.00006893204,0.0001207637,0.0001628255,0.0001568517],"domain_scores_gemma":[0.9993382,0.00008351947,0.0002375716,0.00009862176,0.00009218282,0.0001498347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004609562,0.00003216278,0.0004019017,0.00006108072,0.00001215849,0.0001109418,0.00001642777,0.0001078504,0.9965437,0.000548555,0.000183914,0.001520337],"study_design_scores_gemma":[0.00006280755,0.0001000546,0.006987344,0.00001050574,0.00001550004,0.001205975,0.00004102324,0.001393373,0.9837924,0.0004401161,0.005936989,0.00001383847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.956876,0.01638421,0.01910162,0.001162064,0.0002881449,0.00007516703,0.001788782,0.0003884138,0.00393563],"genre_scores_gemma":[0.9882473,0.001625417,0.005292837,0.0001497439,0.00004603079,0.00007088034,0.001724798,0.00007751886,0.00276545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002519511,"threshold_uncertainty_score":0.008428633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01508414161380357,"score_gpt":0.2155535945582283,"score_spread":0.2004694529444247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}