{"id":"W2152277233","doi":"10.1091/mbc.e02-04-0242","title":"The Intracellular pH-regulatory HCO<sub>3</sub><sup>−</sup>/Cl<sup>−</sup>Exchanger in the Mouse Oocyte Is Inactivated during First Meiotic Metaphase and Reactivated after Egg Activation via the MAP Kinase Pathway","year":2002,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Government of Ontario","keywords":"Maturation promoting factor; Metaphase; Oocyte; Biology; Meiosis; Oocyte activation; MAPK/ERK pathway; Intracellular pH; Sodium–hydrogen antiporter; Cell biology; Molecular biology; Embryo; Intracellular; Chemistry; Biochemistry; Kinase; Cell cycle; Chromosome; Cell; Cyclin-dependent kinase 1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000113113,0.0002540394,0.0001677642,0.0002278814,0.0001220492,0.0003315946,0.0002702315,0.000218458,0.0009642692],"category_scores_gemma":[0.0001208688,0.0001992804,0.0002077589,0.000127677,0.0002556159,0.0003108683,0.0001587264,0.0004378208,0.0004147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003393535,"about_ca_system_score_gemma":0.0002048115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006648477,"about_ca_topic_score_gemma":0.000835929,"domain_scores_codex":[0.9999048,0.000006550993,0.00001059375,0.0000297387,0.00002818908,0.00002023579],"domain_scores_gemma":[0.9998524,0.00001087467,0.00006721953,0.00001580301,0.000016497,0.00003724964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001260144,0.00000338331,0.0003578162,0.00002408255,0.000002047503,0.00002842868,0.000008868902,0.000009638053,0.9984876,0.00009660115,0.00001912454,0.0008363816],"study_design_scores_gemma":[0.00002290938,0.0001093594,0.02803639,0.000007459984,0.00001838277,0.0002744514,0.0000262655,0.0003052696,0.968538,0.00009558492,0.002560718,0.000005224439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871897,0.005912823,0.004140744,0.0001594072,0.00004938271,0.00002903154,0.0006998457,0.0001588648,0.001660193],"genre_scores_gemma":[0.9910713,0.001656655,0.001690287,0.00009109441,0.00002919515,0.00005114028,0.0009646252,0.00005736799,0.004388299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009642692,"threshold_uncertainty_score":0.003225863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009426231642437234,"score_gpt":0.2079658395267285,"score_spread":0.1985396078842913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}