{"id":"W2152284788","doi":"10.1186/s12929-015-0201-8","title":"Reactive oxygen species contribute to dysfunction of bone marrow hematopoietic stem cells in aged C57BL/6 J mice","year":2015,"lang":"en","type":"article","venue":"Journal of Biomedical Science","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Reactive oxygen species; Stem cell; Senescence; Haematopoiesis; Apoptosis; Cell biology; Biology; DNA damage; Superoxide; Immunosenescence; Oxidative stress; Progenitor cell; Xanthine oxidase; Bone marrow; Telomere; Immunology; Andrology; Endocrinology; Biochemistry; Medicine; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002613144,0.0007322695,0.0003497072,0.0009473496,0.0001892757,0.0002681076,0.0002573546,0.0004886225,0.001686428],"category_scores_gemma":[0.0001219604,0.0003253006,0.0003512733,0.0002210706,0.0003281976,0.0002954615,0.0002675297,0.0007313661,0.0002743487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002551969,"about_ca_system_score_gemma":0.0001737955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004194106,"about_ca_topic_score_gemma":0.000586639,"domain_scores_codex":[0.9998313,0.00001902679,0.00002261118,0.00004909694,0.0000410748,0.00003670899],"domain_scores_gemma":[0.9996141,0.00001391919,0.0002014561,0.00001897755,0.00003049464,0.0001209858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008049247,0.0001720453,0.003793329,0.00007195745,0.00002047937,0.0001882108,0.0000444778,0.00005090842,0.9929665,0.00007583792,0.00006465288,0.001746713],"study_design_scores_gemma":[0.0001625342,0.003933477,0.2390127,0.00008309437,0.000294492,0.002336197,0.0002398685,0.001303399,0.7491904,0.0004235031,0.002985961,0.00003438634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963569,0.001586717,0.0009669254,0.00008159355,0.00002207122,0.00002877295,0.0004663866,0.00005868377,0.000431936],"genre_scores_gemma":[0.9934193,0.001309065,0.001722143,0.0001620611,0.00003097615,0.00009017828,0.0007999319,0.00003769572,0.00242852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001686428,"threshold_uncertainty_score":0.005641639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0268766893490206,"score_gpt":0.2749869513752524,"score_spread":0.2481102620262318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}