{"id":"W2152300317","doi":"10.1074/jbc.m414472200","title":"Femtomolar Transition State Analogue Inhibitors of 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Escherichia coli","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Chemistry; Dissociation constant; Stereochemistry; Transition state analog; Escherichia coli; Enzyme; Biochemistry; Active site","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003584532,0.0002342916,0.0004144861,0.00003525469,0.00004602207,0.00002120382,0.0003921195,0.000443751,0.0001690871],"category_scores_gemma":[0.0002501599,0.0001777797,0.0003514627,0.0001651159,0.0002595508,0.000009898679,0.000115116,0.0004579368,0.000005301377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003470039,"about_ca_system_score_gemma":0.0001012787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000168364,"about_ca_topic_score_gemma":0.000001744872,"domain_scores_codex":[0.998211,0.0001121843,0.0007284473,0.0003110526,0.0003274943,0.0003098058],"domain_scores_gemma":[0.9987195,0.00003772604,0.0004043241,0.0002538914,0.0003143285,0.0002702624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005786905,0.0003069852,0.0003504806,0.0000394329,0.0001313296,0.00003516089,0.00002883644,0.00004630511,0.9957535,0.000001325688,0.0009784308,0.001749531],"study_design_scores_gemma":[0.001096841,0.000490366,0.0006992085,0.00005809525,0.00003264855,0.00003954499,0.0000503774,0.00002597569,0.9894862,0.00007649147,0.00773893,0.0002052746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943658,0.003568154,0.0008998213,0.0007326197,0.00004706121,0.00009045968,0.0001216805,0.000007709637,0.000166759],"genre_scores_gemma":[0.9961637,0.0005898113,0.001978625,0.0002745016,0.000707766,0.00000316734,0.0001752271,0.00001906976,0.0000881717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006760499,"threshold_uncertainty_score":0.7249644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01313508190761308,"score_gpt":0.2520936230422686,"score_spread":0.2389585411346555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}