{"id":"W2152300317","doi":"10.1074/jbc.m414472200","title":"Femtomolar Transition State Analogue Inhibitors of 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Escherichia coli","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Chemistry; Dissociation constant; Stereochemistry; Transition state analog; Escherichia coli; Enzyme; Biochemistry; Active site","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001841033,0.0004130156,0.0003433359,0.0001231421,0.0001557578,0.0002246086,0.0004578134,0.0003577697,0.001310051],"category_scores_gemma":[0.0001435067,0.0001940355,0.0002305313,0.0001815423,0.0001365227,0.0001206947,0.000165777,0.0008249179,0.0003240198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004324451,"about_ca_system_score_gemma":0.0001698013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007434998,"about_ca_topic_score_gemma":0.001078279,"domain_scores_codex":[0.9997831,0.00004383309,0.00002162949,0.00004842178,0.00005947671,0.00004363444],"domain_scores_gemma":[0.9998972,0.00002927444,0.00002779017,0.00001041125,0.00001203567,0.00002325689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001635371,0.00008665287,0.00005386653,0.00009617511,0.00001071018,0.00002474758,0.00001519133,0.0002003789,0.9975609,0.0001642239,0.00007610161,0.001547569],"study_design_scores_gemma":[0.00004252461,0.0005575402,0.0003013766,0.00000700083,0.00001204709,0.00008235306,0.000007959869,0.001083465,0.99427,0.00002856313,0.003601364,0.000005853207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706126,0.006925857,0.01360137,0.0002127419,0.000132489,0.0001963335,0.0007420637,0.0003587321,0.007217883],"genre_scores_gemma":[0.9851857,0.002641644,0.007416396,0.00009204428,0.00001359201,0.0001320297,0.001018756,0.00003797757,0.003461909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001310051,"threshold_uncertainty_score":0.004382551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01313508190761308,"score_gpt":0.2520936230422686,"score_spread":0.2389585411346555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}