{"id":"W2152314234","doi":"10.1186/s13073-014-0077-3","title":"Enhancer alterations in cancer: a source for a cell identity crisis","year":2014,"lang":"en","type":"article","venue":"Genome Medicine","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research; National Cancer Institute; Ontario Institute for Cancer Research; National Institutes of Health; Prostate Cancer Canada; Princess Margaret Cancer Foundation; Movember Foundation","keywords":"Enhancer; Epigenetics; Biology; Carcinogenesis; Cell fate determination; Enhancer RNAs; Epigenomics; Cell; Genetics; Regulation of gene expression; Cell type; Cell biology; Cancer research; Cancer; Computational biology; Gene; Gene expression; Transcription factor; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002265942,0.00009884607,0.0001436841,0.00004599283,0.00005556897,0.000009743396,0.0001472001,0.00006459142,0.00005157898],"category_scores_gemma":[0.00003633057,0.00009076394,0.00003936752,0.00007069579,0.00003347934,0.00000250206,0.00004651068,0.00004532158,0.00000438391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002524949,"about_ca_system_score_gemma":0.00003390838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002267128,"about_ca_topic_score_gemma":0.0009865781,"domain_scores_codex":[0.9992957,0.00002072841,0.0001955882,0.0002332531,0.00007007072,0.0001846911],"domain_scores_gemma":[0.9995906,0.00001015649,0.00006389689,0.0002251883,0.0000542391,0.00005587042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003229346,0.00005588383,0.0006454822,0.00007571517,0.00001793164,2.824162e-7,0.0004786375,0.00117846,0.9932216,0.0001530724,0.00279238,0.001348213],"study_design_scores_gemma":[0.01000724,0.002731528,0.01243358,0.0001139914,0.0002035506,0.00001386313,0.001828388,0.02258835,0.1101896,0.004145481,0.8345432,0.001201317],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8817112,0.001481103,0.1146168,0.001095714,0.0001728882,0.0002284795,0.00002027627,0.000005826553,0.0006677057],"genre_scores_gemma":[0.9956603,0.0004069663,0.001009544,0.000788159,0.0005964326,0.0001134215,0.0001498598,0.00001827486,0.001257067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8830321,"threshold_uncertainty_score":0.3701246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007220914704698078,"score_gpt":0.2639331178274433,"score_spread":0.2567122031227452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}