{"id":"W2152327803","doi":"10.1210/me.2011-0046","title":"TSH Receptor Function Is Required for Normal Thyroid Differentiation in Zebrafish","year":2011,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Thyroid Disorders and Treatments","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institutes of Health; Fonds De La Recherche Scientifique - FNRS","keywords":"Zebrafish; Biology; Thyroid; Thyroid hormone receptor; Internal medicine; Thyroid hormone receptor alpha; Endocrinology; Thyroid hormone receptor beta; Morpholino; Gene knockdown; Receptor; Cellular differentiation; Cell biology; Transcription factor; Nuclear receptor; Hormone receptor; Cell culture; Genetics; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002618556,0.0001489941,0.0002381076,0.000166147,0.0000387912,0.00000521658,0.00005839179,0.00009747876,0.0002908341],"category_scores_gemma":[0.00003404793,0.0001415772,0.0001130919,0.0001091585,0.00003679141,0.00006237242,0.00003152812,0.00009254832,0.00007651412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005226966,"about_ca_system_score_gemma":0.00002671547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001055954,"about_ca_topic_score_gemma":0.00003661318,"domain_scores_codex":[0.9989699,0.00003492737,0.0002234364,0.0003056143,0.00009171328,0.0003744515],"domain_scores_gemma":[0.9995663,0.0000118666,0.00006580109,0.0002419818,0.00005304019,0.00006096558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007555923,0.004001543,0.2410855,0.0001902912,0.001129173,0.0004891311,0.002484285,0.00000328796,0.6682321,0.02480102,0.01110363,0.03892415],"study_design_scores_gemma":[0.02731088,0.005724709,0.5675245,0.00004775187,0.0005471762,0.0001297708,0.0003742716,0.0001858519,0.3759078,0.008535574,0.01313865,0.0005730699],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880964,0.0005917736,0.006071128,0.0005424143,0.0003052187,0.0006367379,0.00001371262,0.0000667565,0.003675855],"genre_scores_gemma":[0.9970807,0.00004266513,0.001075916,0.0008988098,0.00003220248,0.0001817072,0.0001600636,0.00002754829,0.0005003309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3264391,"threshold_uncertainty_score":0.5773352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02103336514732657,"score_gpt":0.2498990887041525,"score_spread":0.2288657235568259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}