{"id":"W2152327803","doi":"10.1210/me.2011-0046","title":"TSH Receptor Function Is Required for Normal Thyroid Differentiation in Zebrafish","year":2011,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Thyroid Disorders and Treatments","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institutes of Health; Fonds De La Recherche Scientifique - FNRS","keywords":"Zebrafish; Biology; Thyroid; Thyroid hormone receptor; Internal medicine; Thyroid hormone receptor alpha; Endocrinology; Thyroid hormone receptor beta; Morpholino; Gene knockdown; Receptor; Cellular differentiation; Cell biology; Transcription factor; Nuclear receptor; Hormone receptor; Cell culture; Genetics; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001228041,0.000360007,0.000296444,0.0004022014,0.0003123274,0.0003469184,0.0003337532,0.0004081645,0.002569157],"category_scores_gemma":[0.0002384175,0.0003288974,0.0004568338,0.0001292264,0.0003603005,0.0002780517,0.0003675459,0.0007092269,0.001252958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009761387,"about_ca_system_score_gemma":0.0006829599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009276231,"about_ca_topic_score_gemma":0.01041939,"domain_scores_codex":[0.999792,0.00001192699,0.00002444601,0.00004306367,0.00008719874,0.00004133273],"domain_scores_gemma":[0.9997844,0.00002832257,0.00006944297,0.00001848269,0.00003722144,0.0000621056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002204331,0.000002182658,0.0001113672,0.00001693677,0.000001792955,0.0001096924,0.00001233731,0.00002584197,0.9991006,0.00008551,0.00003549278,0.0004761843],"study_design_scores_gemma":[0.00004750214,0.0001963464,0.02470224,0.00002724511,0.0000446152,0.0008162555,0.0001201031,0.001631364,0.9638125,0.0001997574,0.008373195,0.00002886607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768462,0.003247219,0.008432773,0.0003890486,0.0001030736,0.00006882513,0.002126289,0.0005736963,0.008212916],"genre_scores_gemma":[0.9835696,0.001105212,0.003010905,0.0001465091,0.00001336186,0.00007718563,0.001214359,0.0001549095,0.010708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009276231,"threshold_uncertainty_score":0.01844448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02103336514732657,"score_gpt":0.2498990887041525,"score_spread":0.2288657235568259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}