{"id":"W2152358682","doi":"10.1124/jpet.114.218578","title":"Acute Effects of Brexpiprazole on Serotonin, Dopamine, and Norepinephrine Systems: An In Vivo Electrophysiologic Characterization","year":2014,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mental Health Research Canada; University of Ottawa","funders":"","keywords":"Partial agonist; Autoreceptor; Chemistry; Aripiprazole; Pharmacology; Ventral tegmental area; Agonist; Dopamine receptor D2; Dopamine; Locus coeruleus; Neuroscience; Receptor; Psychology; Dopaminergic; Medicine; Schizophrenia (object-oriented programming); Nucleus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001078045,0.0001477467,0.000285765,0.0001371288,0.00004728826,0.00001670829,0.0001363942,0.00006395584,0.00001753598],"category_scores_gemma":[0.000004687889,0.000119513,0.00002941067,0.0001011909,0.0001433897,0.0002353155,0.00002099309,0.0002149236,8.597341e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002676164,"about_ca_system_score_gemma":0.00001427984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001270684,"about_ca_topic_score_gemma":6.245105e-8,"domain_scores_codex":[0.9988605,0.0003297604,0.0003349952,0.0001764703,0.0001300007,0.0001682178],"domain_scores_gemma":[0.9994712,0.00009041161,0.0002865683,0.00006492114,0.00002650708,0.00006039207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006614171,0.0004013904,0.0005172779,0.00002879006,0.00001150695,0.00003180432,0.000263129,0.0000194959,0.9972856,0.00006986546,0.000003034591,0.0007066685],"study_design_scores_gemma":[0.0020172,0.003388523,0.002250947,0.00002658015,0.0000399653,0.0001763282,0.00001944807,0.0004907086,0.9912008,0.00000941879,0.0002794081,0.0001006798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990203,0.000157156,0.00003049606,0.00007587078,0.0004105961,0.0002843064,0.000003930734,0.000008450963,0.000008861943],"genre_scores_gemma":[0.9975153,0.0004384998,0.00003278969,0.001896436,0.00007689626,0.00001760345,5.30605e-7,0.00001358264,0.000008412916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006084827,"threshold_uncertainty_score":0.4873598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01760576827462429,"score_gpt":0.3185698200452747,"score_spread":0.3009640517706504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}