{"id":"W2152365387","doi":"10.1152/ajpregu.00417.2010","title":"Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle","year":2011,"lang":"en","type":"article","venue":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Queen's University; University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"Mitochondrial biogenesis; Skeletal muscle; Biology; Mitochondrion; Citrate synthase; Coactivator; Biogenesis; Sirtuin 1; Organelle biogenesis; Internal medicine; Nuclear protein; Endocrinology; Cell biology; Biochemistry; Transcription factor; Gene; Downregulation and upregulation; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0002192404,0.0004980878,0.001971246,0.0003786842,0.000176665,0.00001221099,0.0002111026,0.0001565477,0.0001249504],"category_scores_gemma":[0.00005930213,0.0003237264,0.0002535981,0.0002854277,0.003670147,0.0002012389,0.0001151825,0.000736677,0.000004915936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007412049,"about_ca_system_score_gemma":0.0001084402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005240061,"about_ca_topic_score_gemma":0.00006268035,"domain_scores_codex":[0.997387,0.0006575758,0.000716903,0.0005666373,0.0002255458,0.0004463728],"domain_scores_gemma":[0.9979795,0.0001680116,0.0008579641,0.0003112091,0.0003999819,0.000283381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003238087,0.0005240869,0.001151925,0.00003067024,0.0004229715,0.00002446569,0.002416036,0.000002291244,0.9882808,0.001805935,0.0001974309,0.001905282],"study_design_scores_gemma":[0.003737711,0.01141626,0.7122857,0.000285336,0.0001549822,0.0001361517,0.008923677,0.00007963038,0.2615691,0.0007866404,0.0002846162,0.0003401764],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984593,0.0003727702,0.00001565884,0.0002544551,0.0002242257,0.0004899138,0.00001171085,0.00001824144,0.0001536796],"genre_scores_gemma":[0.9980669,0.00008840995,0.0008491191,0.0003814775,0.0004376015,0.00002436102,0.00000815855,0.00002870978,0.0001152663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7267117,"threshold_uncertainty_score":0.9999215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04894095393651009,"score_gpt":0.2903667849529079,"score_spread":0.2414258310163978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}