{"id":"W2152365387","doi":"10.1152/ajpregu.00417.2010","title":"Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle","year":2011,"lang":"en","type":"article","venue":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Queen's University; University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"Mitochondrial biogenesis; Skeletal muscle; Biology; Mitochondrion; Citrate synthase; Coactivator; Biogenesis; Sirtuin 1; Organelle biogenesis; Internal medicine; Nuclear protein; Endocrinology; Cell biology; Biochemistry; Transcription factor; Gene; Downregulation and upregulation; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001630713,0.0002277925,0.0002062619,0.000290881,0.00009665384,0.0002083651,0.0001083249,0.0001480163,0.001461459],"category_scores_gemma":[0.0001717938,0.000207958,0.0003206985,0.0002517521,0.0002512325,0.000143085,0.0001239425,0.0002524682,0.0004085312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002124779,"about_ca_system_score_gemma":0.0001080975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006984244,"about_ca_topic_score_gemma":0.001296274,"domain_scores_codex":[0.9999102,0.00001414443,0.000006412482,0.00003513062,0.00001795354,0.00001610331],"domain_scores_gemma":[0.9999311,0.000009528853,0.00002594978,0.000009416331,0.000009492845,0.00001439281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001475537,0.00007181335,0.007317754,0.0001057908,0.00005099046,0.00008452898,0.00007582984,0.00008141144,0.9835017,0.00005928889,0.0001660192,0.00700941],"study_design_scores_gemma":[0.0001880994,0.002392054,0.5051111,0.00003275774,0.0002864322,0.001326499,0.0002246829,0.001716766,0.4835485,0.0001856618,0.004961847,0.00002561136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908469,0.006681771,0.001207862,0.00008455971,0.00003175695,0.00001170673,0.0003681574,0.00005948673,0.0007077195],"genre_scores_gemma":[0.9944981,0.002189139,0.0007337651,0.0000452643,0.00001777263,0.00002395054,0.0008736059,0.00001611398,0.001602427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001461459,"threshold_uncertainty_score":0.004889011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04894095393651009,"score_gpt":0.2903667849529079,"score_spread":0.2414258310163978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}