{"id":"W2152395868","doi":"10.1186/bcr3052","title":"Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2","year":2011,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; Université Laval; University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Centre hospitalier universitaire de Québec; St. Michael's Hospital","funders":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco; National Cancer Institute; National Health and Medical Research Council; Canadian Institutes of Health Research; Cancer Center, University of Kansas; Fox Chase Cancer Center; ZonMw; Centre Léon Bérard; National Institutes of Health; Centre Hospitalier Universitaire de Nantes; Universiteit Leiden; Institut Claudius Regaud; Fondazione Italiana per la Ricerca sul Cancro; Radboud Universitair Medisch Centrum; Institut Bergonié; Deutsche Krebshilfe; Leids Universitair Medisch Centrum; Associazione Italiana per la Ricerca sul Cancro; Royal Marsden NHS Foundation Trust; Umeå Universitet; Istituto Oncologico Veneto; U.S. Public Health Service; Lietuvos Mokslo Taryba; Landspítali Háskólasjúkrahús; Lunds Universitet; Ministero della Salute; University of Pennsylvania; Institut Gustave-Roussy; Sahlgrenska Universitetssjukhuset; Erasmus Medisch Centrum; Vrije Universiteit Amsterdam; Huntsman Cancer Institute; Cancer Australia; National Breast Cancer Foundation; National Institute for Health and Care Research; Avon Foundation for Women; Universitair Medisch Centrum Groningen; Deutsches Krebsforschungszentrum; Linköpings Universitet; Alleanza Contro il Cancro; Canadian Breast Cancer Research Alliance; University of California, San Francisco; Creighton University; Helsingin ja Uudenmaan Sairaanhoitopiiri; Medical Research Council; Uppsala Universitet; Memorial Sloan-Kettering Cancer Center; Ohio State University; Radboud Universiteit; Kansas Bioscience Authority; Akademiska Sjukhuset; Cancer Care Ontario; KWF Kankerbestrijding; Cancer Research UK; Georgetown University; Breast Cancer Research Foundation","keywords":"Surgical oncology; Breast cancer; BRCA2 Protein; Allele; Medicine; Oncology; Mutation; Cancer research; Genetics; Cancer; Internal medicine; Biology; Germline mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003214928,0.0004893692,0.0004442272,0.001125533,0.0004122944,0.0006691884,0.0006121391,0.0006469387,0.00145952],"category_scores_gemma":[0.007008413,0.0003525472,0.001005925,0.001369787,0.0004461033,0.0002315888,0.000700618,0.0003932281,0.0001609836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001849861,"about_ca_system_score_gemma":0.0003071393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004019602,"about_ca_topic_score_gemma":0.002622824,"domain_scores_codex":[0.9982129,0.0005683457,0.0001646869,0.0006217507,0.0003034259,0.0001288477],"domain_scores_gemma":[0.9943053,0.002017481,0.001849345,0.0009309822,0.0004544791,0.0004424861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001342248,0.00002091755,0.9945554,0.00002304574,0.0005662551,0.0001021044,0.00009638769,0.00007529409,0.00108828,0.00002862203,0.00006510321,0.002036415],"study_design_scores_gemma":[0.0000482377,0.0001331469,0.9985188,0.000006849343,0.0003917438,0.0003177685,0.00005109904,0.0001011736,0.0002184377,0.00003003886,0.0001768173,0.000006034824],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981846,0.0007760524,0.0002293729,0.00002845167,0.000007083694,0.00001214891,0.0005315713,0.000005295418,0.0002252208],"genre_scores_gemma":[0.9987895,0.000237387,0.0001488964,0.00002189166,0.00001417551,0.00001285232,0.0006331308,0.000005069808,0.0001371135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004019602,"threshold_uncertainty_score":0.01700234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05005496948432958,"score_gpt":0.3210897398061939,"score_spread":0.2710347703218643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}