{"id":"W2152395868","doi":"10.1186/bcr3052","title":"Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2","year":2011,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; Université Laval; University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Centre hospitalier universitaire de Québec; St. Michael's Hospital","funders":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco; National Cancer Institute; National Health and Medical Research Council; Canadian Institutes of Health Research; Cancer Center, University of Kansas; Fox Chase Cancer Center; ZonMw; Centre Léon Bérard; National Institutes of Health; Centre Hospitalier Universitaire de Nantes; Universiteit Leiden; Institut Claudius Regaud; Fondazione Italiana per la Ricerca sul Cancro; Radboud Universitair Medisch Centrum; Institut Bergonié; Deutsche Krebshilfe; Leids Universitair Medisch Centrum; Associazione Italiana per la Ricerca sul Cancro; Royal Marsden NHS Foundation Trust; Umeå Universitet; Istituto Oncologico Veneto; U.S. Public Health Service; Lietuvos Mokslo Taryba; Landspítali Háskólasjúkrahús; Lunds Universitet; Ministero della Salute; University of Pennsylvania; Institut Gustave-Roussy; Sahlgrenska Universitetssjukhuset; Erasmus Medisch Centrum; Vrije Universiteit Amsterdam; Huntsman Cancer Institute; Cancer Australia; National Breast Cancer Foundation; National Institute for Health and Care Research; Avon Foundation for Women; Universitair Medisch Centrum Groningen; Deutsches Krebsforschungszentrum; Linköpings Universitet; Alleanza Contro il Cancro; Canadian Breast Cancer Research Alliance; University of California, San Francisco; Creighton University; Helsingin ja Uudenmaan Sairaanhoitopiiri; Medical Research Council; Uppsala Universitet; Memorial Sloan-Kettering Cancer Center; Ohio State University; Radboud Universiteit; Kansas Bioscience Authority; Akademiska Sjukhuset; Cancer Care Ontario; KWF Kankerbestrijding; Cancer Research UK; Georgetown University; Breast Cancer Research Foundation","keywords":"Surgical oncology; Breast cancer; BRCA2 Protein; Allele; Medicine; Oncology; Mutation; Cancer research; Genetics; Cancer; Internal medicine; Biology; Germline mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001021316,0.0001680592,0.0003325694,0.0001084884,0.00007425454,0.00001123156,0.0003441156,0.0001749281,0.00004968898],"category_scores_gemma":[0.0002731033,0.0001319095,0.00005098648,0.0004909473,0.001509178,0.00001622004,0.00013832,0.0002580664,2.125999e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002159429,"about_ca_system_score_gemma":0.001250255,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.0746925,"about_ca_topic_score_gemma":0.08909083,"domain_scores_codex":[0.9977311,0.0004917452,0.0005063235,0.0004816991,0.0004734679,0.00031563],"domain_scores_gemma":[0.9979062,0.0001615401,0.0004113113,0.0004860732,0.0009326626,0.0001022211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003115175,0.0001718097,0.8807351,0.00009634651,0.0003722182,0.000004464916,0.0040698,0.0006553976,0.1078253,0.00004034204,0.0005779358,0.002336098],"study_design_scores_gemma":[0.001475636,0.0001092786,0.8272524,0.0002604605,0.00003363855,0.000006434807,0.003092617,0.000100874,0.1673745,0.0001566815,0.0000140406,0.0001235024],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922357,0.00140845,0.000005331635,0.0006095155,0.00004394809,0.0004089928,0.005159359,0.000005079372,0.0001236166],"genre_scores_gemma":[0.9992887,0.0003093776,0.00006336523,0.00003090726,0.00004958015,0.00008811115,0.0001212023,0.00002637595,0.00002237853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05954915,"threshold_uncertainty_score":0.9314692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05005496948432958,"score_gpt":0.3210897398061939,"score_spread":0.2710347703218643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}