{"id":"W2152445171","doi":"10.1158/1535-7163.1193.3.10","title":"Targeting heterogeneous nuclear ribonucleoparticule A1 and A2 proteins by RNA interference promotes cell death in transformed but not in normal mouse cell lines","year":2004,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Gene knockdown; RNA interference; Biology; HeLa; Telomere; Telomerase; Molecular biology; Cell biology; Cell culture; Small interfering RNA; RNA; Complementary DNA; Nuclear protein; Cell; Transfection; Gene; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002296873,0.000428568,0.0002848222,0.0005627461,0.0001893529,0.0004047584,0.0002404204,0.0002945289,0.001114076],"category_scores_gemma":[0.0001728405,0.000200827,0.0003361037,0.0002231971,0.0002806928,0.0001804668,0.0001701931,0.000678289,0.0004452265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003004954,"about_ca_system_score_gemma":0.0002321678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005329166,"about_ca_topic_score_gemma":0.0009795228,"domain_scores_codex":[0.9997354,0.00003953533,0.00003395636,0.00005859332,0.00008462711,0.00004785779],"domain_scores_gemma":[0.9997726,0.0000515723,0.00005951303,0.00003871346,0.00002088269,0.00005674593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006098444,0.00001905538,0.00006249861,0.000009334854,0.000005412222,0.00003106634,0.000009128532,0.00002906669,0.9993111,0.00009338127,0.00002390915,0.0003451368],"study_design_scores_gemma":[0.00001936682,0.0002916848,0.001541023,0.000003414055,0.00001480003,0.0002542257,0.00001444632,0.0007233644,0.9952759,0.00004444281,0.00181473,0.000002659678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904811,0.001771173,0.005105451,0.0001111713,0.00003693146,0.00003494287,0.0004155661,0.0002214825,0.001822172],"genre_scores_gemma":[0.9875427,0.001331103,0.004742578,0.00005629536,0.00001667143,0.00008405915,0.001205973,0.0000528901,0.004967654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001114076,"threshold_uncertainty_score":0.003726959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01786774268267927,"score_gpt":0.2511694706790178,"score_spread":0.2333017279963386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}