{"id":"W2152451684","doi":"10.3899/jrheum.140022","title":"Rheumatoid Arthritis Clinical Benefits from Abatacept, Cytokine Blockers, and Rituximab Are All Linked to Modulation of Memory B Cell Responses","year":2014,"lang":"en","type":"letter","venue":"The Journal of Rheumatology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases","keywords":"CD80; Abatacept; Medicine; Rituximab; Immunology; Immune system; B cell; Rheumatoid arthritis; CD86; T cell; Memory T cell; Cytokine; Cytotoxic T cell; Arthritis; CD28; Cancer research; Lymphoma; Antibody; CD40; Biology; In vitro","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004445541,0.0005793582,0.0008429543,0.0005274221,0.0002360494,0.000350226,0.0001942956,0.0006290301,0.005437797],"category_scores_gemma":[0.0007382435,0.00009764908,0.0004434646,0.000237984,0.0001967579,0.0001945605,0.0002358444,0.000847271,0.001197719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002247067,"about_ca_system_score_gemma":0.0002730726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003719137,"about_ca_topic_score_gemma":0.0005393074,"domain_scores_codex":[0.9997781,0.00005528669,0.00002111428,0.00002107968,0.00008871135,0.00003575754],"domain_scores_gemma":[0.9996834,0.00007682745,0.00009357807,0.00001575132,0.00006969628,0.0000608241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009029884,0.001346698,0.01101384,0.004597278,0.0006576927,0.001082211,0.00007041483,0.0003204229,0.06307753,0.001401624,0.01976357,0.887639],"study_design_scores_gemma":[0.008494185,0.03359557,0.514486,0.003700925,0.003999271,0.01998717,0.0002494064,0.001210598,0.03204454,0.005893198,0.3762035,0.0001355544],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.2076507,0.7277834,0.002497565,0.008453649,0.001991861,0.0002046936,0.0009798323,0.0005080143,0.04993029],"genre_scores_gemma":[0.786164,0.1842875,0.003732792,0.008054556,0.005100857,0.0002207692,0.001191922,0.00005746046,0.01119004],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.005437797,"threshold_uncertainty_score":0.01819122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02312756183859264,"score_gpt":0.2509991203680565,"score_spread":0.2278715585294639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}