{"id":"W2152469540","doi":"10.2217/epi.12.62","title":"Epigenome-Wide Analysis in Familial Hypercholesterolemia Identified New Loci Associated with High-Density Lipoprotein Cholesterol Concentration","year":2012,"lang":"en","type":"article","venue":"Epigenomics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University and Génome Québec Innovation Centre; Cégep de Chicoutimi; Université de Montréal; Université de Sherbrooke","funders":"NIH Clinical Center; Canadian Institutes of Health Research","keywords":"Biology; DNA methylation; Epigenome; Epigenetics; Genetics; Apolipoprotein B; Cholesterol; Dyslipidemia; High-density lipoprotein; Internal medicine; Endocrinology; Gene; Gene expression; Medicine; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005954182,0.0002696213,0.0003527135,0.0001240296,0.0001034796,0.00006896204,0.0002007414,0.0003033862,0.00001592135],"category_scores_gemma":[0.0001335852,0.0002751042,0.0001253296,0.0004026291,0.00006592289,0.00002476045,0.00007976956,0.0001788363,0.00001577622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00014846,"about_ca_system_score_gemma":0.0001274468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001366411,"about_ca_topic_score_gemma":0.008459233,"domain_scores_codex":[0.9981699,0.0001861742,0.0004483036,0.0004601993,0.0001960127,0.0005393862],"domain_scores_gemma":[0.9989172,0.00003151949,0.0002400823,0.0004742116,0.0000991569,0.0002378537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002109619,0.0002080166,0.7535039,0.000007988611,0.0004739398,0.000002592432,0.0006431616,0.005132312,0.2332814,0.00004056953,0.00002951699,0.006465636],"study_design_scores_gemma":[0.001052434,0.0001310977,0.8408819,0.00000766912,0.0001861971,2.450313e-7,0.00004977378,0.00005791951,0.1564631,0.00009163195,0.0007712414,0.0003067561],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871351,0.0008042278,0.01121541,0.00009754,0.0001617329,0.0003841441,0.00002615618,0.00001778853,0.0001579262],"genre_scores_gemma":[0.9969233,0.0003126991,0.0006437566,0.0001769743,0.0003582694,0.00001642417,0.001017298,0.00004095974,0.0005103149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08737796,"threshold_uncertainty_score":0.9999701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01188826895906534,"score_gpt":0.2311146155761539,"score_spread":0.2192263466170885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}