{"id":"W2152488413","doi":"10.1002/em.21727","title":"Quantitative approaches for assessing dose–response relationships in genetic toxicology studies","year":2012,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Genotoxicity; Methyl methanesulfonate; Micronucleus test; Ethyl methanesulfonate; Toxicology; In vivo; Point of delivery; Risk assessment; Computational biology; Toxicogenomics; Biology; Mode of action; Pharmacology; Statistics; Genetics; Toxicity; Computer science; Mathematics; Medicine; Gene; Mutation; DNA repair; Gene expression; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05826218,0.003098424,0.002198389,0.008401251,0.0009027455,0.004214393,0.004834886,0.002759368,0.003749154],"category_scores_gemma":[0.08976141,0.001516753,0.00415356,0.006674727,0.002778669,0.003699378,0.003925761,0.005457199,0.001215828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00386463,"about_ca_system_score_gemma":0.002505282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002774932,"about_ca_topic_score_gemma":0.002997893,"domain_scores_codex":[0.9299042,0.04401202,0.004165734,0.005270491,0.01597943,0.0006681327],"domain_scores_gemma":[0.9098195,0.06353983,0.009988086,0.009754563,0.006556771,0.0003412405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.000935673,0.002165002,0.03390214,0.01010456,0.003832944,0.0005828589,0.002094052,0.2426196,0.1630051,0.1382598,0.005345562,0.3971527],"study_design_scores_gemma":[0.0002347133,0.006255839,0.0361243,0.001387988,0.001875923,0.001445085,0.002142958,0.5006032,0.1240985,0.2532673,0.07156455,0.0009996033],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.006606056,0.001477207,0.9862592,0.0002290249,0.0000924218,0.001391709,0.0009738944,0.0006570149,0.002313451],"genre_scores_gemma":[0.1440459,0.002635199,0.8423073,0.0007632902,0.0001320261,0.005723249,0.001847274,0.0004541508,0.002091722],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.05826218,"threshold_uncertainty_score":0.3081236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07167322889074622,"score_gpt":0.3091444765778238,"score_spread":0.2374712476870776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}