{"id":"W2152532229","doi":"10.1161/hypertensionaha.110.152298","title":"Candidate Genes and Mechanisms for 2-Methoxyestradiol–Mediated Vasoprotection","year":2010,"lang":"en","type":"article","venue":"Hypertension","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Downregulation and upregulation; Biology; Cyclin D1; Cell biology; Microarray analysis techniques; Peroxisome proliferator-activated receptor; Cell growth; Vascular smooth muscle; Endocrinology; Internal medicine; Cancer research; Receptor; Cell cycle; Gene expression; Cell; Biochemistry; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001618222,0.0001402462,0.0001310127,0.00004584572,0.000132531,0.00002081662,0.00006496141,0.0002691627,0.0000088783],"category_scores_gemma":[0.000151073,0.0001200072,0.00004486054,0.00005560625,0.00004447193,0.000005451272,0.00004016229,0.0001247544,0.000004183921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004807405,"about_ca_system_score_gemma":0.0000348461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002411386,"about_ca_topic_score_gemma":0.00003930391,"domain_scores_codex":[0.9992529,0.00002794607,0.0001176038,0.00033364,0.00007303527,0.0001948444],"domain_scores_gemma":[0.9995362,0.00001600248,0.00004879517,0.0002003001,0.000098856,0.00009985313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008293892,0.00002129966,0.0001662745,0.000009990228,0.00002300337,8.635455e-7,0.000006233197,0.000001549968,0.9943212,0.00005465405,0.0003976836,0.00491431],"study_design_scores_gemma":[0.000571577,0.0002296361,0.0002706238,0.000004886839,0.00001751636,0.0001134044,0.0000180758,0.0004715581,0.9795454,0.0002666149,0.0183251,0.00016564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877657,0.000233826,0.01087025,0.0001498705,0.0005500566,0.0003414973,0.00002175897,0.00003439456,0.00003261953],"genre_scores_gemma":[0.9906194,0.0001384421,0.008398686,0.0002696753,0.0002431118,0.00007064926,0.0001511174,0.00003160614,0.00007728042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01792742,"threshold_uncertainty_score":0.489375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01031739611749852,"score_gpt":0.2270507605080877,"score_spread":0.2167333643905892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}