{"id":"W2152553492","doi":"10.1111/j.1399-0004.2008.01099.x","title":"Squalene synthase: a critical enzyme in the cholesterol biosynthesis pathway","year":2008,"lang":"en","type":"review","venue":"Clinical Genetics","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi; McGill University","funders":"","keywords":"Squalene; Farnesyl-diphosphate farnesyltransferase; Cholesterol; Sterol; Farnesyltransferase; ATP synthase; Squalene monooxygenase; Biochemistry; Enzyme; Biology; Chemistry; Biosynthesis; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002206413,0.0009362788,0.001033154,0.001444641,0.0002646877,0.0007974846,0.0006264652,0.000745198,0.002433203],"category_scores_gemma":[0.0002063377,0.0002305392,0.0002710685,0.001739956,0.0004457035,0.001193236,0.000441234,0.0009704849,0.004186128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006221089,"about_ca_system_score_gemma":0.0009611927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008005732,"about_ca_topic_score_gemma":0.00111476,"domain_scores_codex":[0.9998932,0.00001358854,0.00001437252,0.00002404985,0.0000433596,0.00001137351],"domain_scores_gemma":[0.9999288,0.00001771062,0.00001387891,0.000002707772,0.00002425807,0.00001265155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008713737,0.00005148312,0.0003538348,0.009776249,0.00005556173,0.0004631886,0.00006467217,0.0003707139,0.01405798,0.003843308,0.01801721,0.9528587],"study_design_scores_gemma":[0.00001319401,0.00004980591,0.0008187236,0.0007293701,0.00003988948,0.00183024,0.00004738863,0.00005521356,0.002018592,0.001727,0.9926575,0.00001313856],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003887388,0.9957395,0.0004675899,0.0002825199,0.000225033,0.000008485014,0.00003066114,0.00002335707,0.002834208],"genre_scores_gemma":[0.001814912,0.9952609,0.0005110882,0.0001168238,0.0001336478,0.000007605931,0.00006228776,0.00000227143,0.00209043],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002433203,"threshold_uncertainty_score":0.008139908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1092046903015216,"score_gpt":0.4026120116894582,"score_spread":0.2934073213879367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}