{"id":"W2152568000","doi":"10.1073/pnas.97.3.1119","title":"Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity","year":2000,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Medical Research Council; National Institutes of Health; Medical Research Council Canada","keywords":"Internalization; Endocytic cycle; Biology; G protein-coupled receptor kinase; G protein-coupled receptor; Cell biology; Receptor; GTPase-activating protein; Signal transducing adaptor protein; Clathrin; G protein; Arrestin; Signal transduction; Endocytosis; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002081435,0.0006100031,0.000398106,0.0004158177,0.0002229518,0.0006263216,0.0002904307,0.0004997989,0.0007979468],"category_scores_gemma":[0.0001640454,0.0002308861,0.0005701295,0.0001989402,0.0005047967,0.00040215,0.0005414088,0.0009569551,0.000396234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009671694,"about_ca_system_score_gemma":0.0001541235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006793578,"about_ca_topic_score_gemma":0.0008866185,"domain_scores_codex":[0.9998057,0.00002337274,0.0000123175,0.0000420615,0.0000666326,0.00004992203],"domain_scores_gemma":[0.9998492,0.00002417024,0.00004953309,0.0000184725,0.00002534153,0.00003316034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008499069,0.000005550742,0.0002739773,0.00003848921,0.000008113206,0.0001511551,0.00002425559,0.0001066263,0.9979545,0.0002880561,0.0000473247,0.00101698],"study_design_scores_gemma":[0.00001520171,0.0001247888,0.01564305,0.00001208662,0.00004653689,0.00150419,0.00003759819,0.001642781,0.9780602,0.0003096253,0.00258928,0.00001478683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834359,0.007905626,0.005226212,0.0004387148,0.00002744222,0.00004260111,0.0004355463,0.000230315,0.00225769],"genre_scores_gemma":[0.9900631,0.003599633,0.003488665,0.0001743605,0.00001477255,0.0000509665,0.0005452809,0.00005461112,0.002008586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009671694,"threshold_uncertainty_score":0.007017374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02128126993717284,"score_gpt":0.2506328744260926,"score_spread":0.2293516044889198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}