{"id":"W2152583686","doi":"10.1126/scitranslmed.3002289","title":"A Common Mutation in the Defensin <i>DEFB126</i> Causes Impaired Sperm Function and Subfertility","year":2011,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Wellcome Trust","keywords":"Defensin; Cervical mucus; Frameshift mutation; Sperm; Mutation; Biology; Infertility; Genetics; Immunology; Andrology; Medicine; Gene; Cervix","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001600137,0.0009749677,0.0004349673,0.0005805176,0.0002909229,0.0001560566,0.0002745471,0.0005909236,0.002767748],"category_scores_gemma":[0.0003401231,0.0002041907,0.0004082322,0.0004183159,0.000458184,0.0001045075,0.0003979249,0.000391809,0.0003480396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001819919,"about_ca_system_score_gemma":0.0001129888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007158605,"about_ca_topic_score_gemma":0.0006670573,"domain_scores_codex":[0.9998031,0.00003670245,0.00002767972,0.00006076813,0.00004769108,0.00002406094],"domain_scores_gemma":[0.9997292,0.00004377446,0.0001255236,0.00001533358,0.00001283771,0.0000733106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002495302,0.0004329384,0.0882644,0.0002439738,0.0003740777,0.04558171,0.0002986691,0.0004875432,0.8408226,0.0007435672,0.001658945,0.01859623],"study_design_scores_gemma":[0.0003957973,0.00265281,0.7410116,0.00009230465,0.0003150324,0.1773482,0.0002622104,0.00263757,0.06565222,0.0004896416,0.009060379,0.00008221796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967971,0.0004054644,0.001223342,0.0001016783,0.00003683969,0.00003231808,0.0005380186,0.00008288179,0.0007823087],"genre_scores_gemma":[0.9978091,0.0001867669,0.0006713391,0.00008843587,0.00002973643,0.000009004927,0.0003899617,0.00001658355,0.0007991509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002767748,"threshold_uncertainty_score":0.009259045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02725892066892603,"score_gpt":0.2557597233787844,"score_spread":0.2285008027098584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}