{"id":"W2152589229","doi":"10.1093/hmg/ddi447","title":"Spastin and atlastin, two proteins mutated in autosomal-dominant hereditary spastic paraplegia, are binding partners","year":2005,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; National Institutes of Health; Cambridge Commonwealth Trust; University of Toronto; National Science Council; Wellcome Trust","keywords":"Hereditary spastic paraplegia; Biology; Cell biology; Gene isoform; Genetics; Gene; Phenotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001588401,0.0004025907,0.0003587155,0.0002332453,0.0002018187,0.00008095627,0.0003819984,0.0001392597,0.000103788],"category_scores_gemma":[0.0005384295,0.0004031225,0.00007906856,0.0004635256,0.0003941093,0.0001023251,0.0002303108,0.0004624655,0.0001020856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005604844,"about_ca_system_score_gemma":0.00006161616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003367841,"about_ca_topic_score_gemma":0.0002932762,"domain_scores_codex":[0.9968929,0.0003592705,0.0005240574,0.0009579313,0.0004548248,0.000811005],"domain_scores_gemma":[0.9989667,0.0001512989,0.0001748138,0.000407208,0.00003233469,0.0002676341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005471201,0.0002962238,0.008384422,0.00003866256,0.000008045669,0.003008723,0.0002023065,0.01526795,0.9708918,0.0004505159,0.0001997902,0.001196792],"study_design_scores_gemma":[0.00823067,0.001837983,0.2633488,0.000304521,0.0001066543,0.0006055494,0.0002713456,0.06202295,0.6517349,0.002482617,0.00671057,0.002343365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967638,0.000219798,0.0005753429,0.0007527202,0.0001174194,0.0008036514,0.00001838179,0.0001165422,0.0006323524],"genre_scores_gemma":[0.9975693,0.00003455278,0.0009683002,0.001098505,0.0001020543,0.0000633841,0.00001114587,0.00006833143,0.00008441694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3191569,"threshold_uncertainty_score":0.999842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03638803331932904,"score_gpt":0.2958857397468788,"score_spread":0.2594977064275497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}