{"id":"W2152595005","doi":"10.1042/bsr20140051","title":"Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis","year":2014,"lang":"en","type":"article","venue":"Bioscience Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; Fondation pour la Recherche Médicale; Cancer Research UK; Canadian Institutes of Health Research; Cancer Research Society; University of Dundee; Killam Trusts; University of Calgary","keywords":"DNA-PKcs; Autophosphorylation; Cell biology; PLK1; Mitosis; Biology; Polo-like kinase; Protein kinase A; Phosphorylation; Biochemistry; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001030507,0.0006003117,0.0002358177,0.0003302292,0.0002952064,0.0005115038,0.000195147,0.0003072213,0.001821175],"category_scores_gemma":[0.0001351072,0.0002554861,0.0003489268,0.0001634064,0.0002757551,0.0004313298,0.0004562487,0.0005230655,0.0009634561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000391133,"about_ca_system_score_gemma":0.000198357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003132059,"about_ca_topic_score_gemma":0.0004207691,"domain_scores_codex":[0.999873,0.000009366292,0.00001027618,0.00004892493,0.0000254502,0.00003290995],"domain_scores_gemma":[0.9998769,0.000007883224,0.00005902987,0.000006126517,0.00001226729,0.00003788627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003512191,0.00005207086,0.001792777,0.0001659521,0.00001008883,0.000180328,0.00003257305,0.0001766907,0.9918457,0.0002692985,0.0002301544,0.004893191],"study_design_scores_gemma":[0.0000784792,0.0004122967,0.06166696,0.00002909257,0.0000386282,0.001127446,0.0001052765,0.00145739,0.9236464,0.0005605669,0.01086116,0.00001626295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9489828,0.035444,0.007734617,0.0004039433,0.0002602901,0.00008968855,0.0009871582,0.0004322815,0.005665065],"genre_scores_gemma":[0.9788938,0.0101008,0.002219757,0.0001347111,0.00007974546,0.0000522825,0.001134201,0.00003273721,0.007351851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001821175,"threshold_uncertainty_score":0.00609237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00699564477391039,"score_gpt":0.2180193631163516,"score_spread":0.2110237183424412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}