{"id":"W2152596956","doi":"10.1002/anie.200605219","title":"Chemistry and Biology of the Aeruginosin Family of Serine Protease Inhibitors","year":2007,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":225,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Montréal","funders":"","keywords":"Proteases; Serine; Chemistry; Serine protease; Amino acid; Biochemistry; Stereochemistry; Peptide; Protease; Structural biology; Structural chemistry; Chemical biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113062,0.0003254029,0.0001584486,0.000200332,0.0001599354,0.0003465379,0.0001891499,0.0002129533,0.0006042062],"category_scores_gemma":[0.00008733394,0.0001155134,0.0001061656,0.0001675891,0.0001908321,0.0003841216,0.0001493221,0.0003658201,0.0003728228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004431606,"about_ca_system_score_gemma":0.0002406151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006719691,"about_ca_topic_score_gemma":0.0005274045,"domain_scores_codex":[0.9999473,0.00001053745,0.000002895692,0.000009267966,0.00001921023,0.00001078155],"domain_scores_gemma":[0.9999753,0.000002890807,0.000005504118,0.000002081799,0.000006963792,0.000007355617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001137699,0.00003207395,0.000284641,0.0003441057,0.00001994586,0.0003741856,0.00007003209,0.001700351,0.9347731,0.0110284,0.0009852736,0.05027404],"study_design_scores_gemma":[0.00002852333,0.0002734483,0.001502261,0.00002745527,0.00001685642,0.001283728,0.00003324924,0.001768443,0.8347803,0.002752225,0.1575135,0.00001998736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5295979,0.3411838,0.0638331,0.003719909,0.0005345179,0.0001530957,0.0006209718,0.0005700162,0.05978667],"genre_scores_gemma":[0.8726637,0.09581392,0.01013244,0.0003794387,0.000211053,0.00008280797,0.0003455472,0.00003109124,0.02033994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006719691,"threshold_uncertainty_score":0.003215373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009290873400495673,"score_gpt":0.2508436628707951,"score_spread":0.2415527894702995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}