{"id":"W2152622855","doi":"10.1007/s00424-005-1505-4","title":"Two-pore-domain potassium channels support anion secretion from human airway Calu-3 epithelial cells","year":2005,"lang":"en","type":"article","venue":"Pflügers Archiv - European Journal of Physiology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cystic fibrosis transmembrane conductance regulator; Secretion; Apical membrane; Potassium channel; Membrane potential; Epithelial polarity; Cell biology; Ion channel; Ion transporter; Biology; Epithelial sodium channel; Patch clamp; Intracellular; Epithelium; Chemistry; Internal medicine; Cell; Endocrinology; Biophysics; Biochemistry; Sodium; Receptor; Medicine; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006362837,0.000293091,0.0006876666,0.0002255843,0.0004802972,0.001159339,0.0003660683,0.0007942875,0.002043327],"category_scores_gemma":[0.00109862,0.0001684596,0.0006493281,0.0002585388,0.0003107601,0.0009107809,0.0006879374,0.001198399,0.0007649894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004895444,"about_ca_system_score_gemma":0.0005854724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001492068,"about_ca_topic_score_gemma":0.001505584,"domain_scores_codex":[0.99922,0.0001316871,0.000108621,0.00007574974,0.0001886604,0.0002752708],"domain_scores_gemma":[0.9994425,0.0002107755,0.00004117749,0.0001198589,0.00009319923,0.00009245033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001011083,0.00006946738,0.0005392331,0.00007939146,0.00001412673,0.0001556409,0.0001462588,0.0000508576,0.9959309,0.0002158263,0.0004104693,0.001376881],"study_design_scores_gemma":[0.0004809665,0.0008052987,0.01559012,0.0000182466,0.0000679033,0.0008445912,0.0006509976,0.00292285,0.9673877,0.000325691,0.01087916,0.00002631246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940432,0.001574617,0.001157224,0.000934662,0.000163824,0.00004011711,0.0009555448,0.00006911541,0.001061892],"genre_scores_gemma":[0.9954239,0.000402195,0.0009957764,0.0002385218,0.00004939368,0.00003291298,0.0014787,0.00002655568,0.001352038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002043327,"threshold_uncertainty_score":0.006835639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418418276921872,"score_gpt":0.2819718974465264,"score_spread":0.2677877146773077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}