{"id":"W2152651890","doi":"10.1099/mic.0.26209-0","title":"Control of growth, secondary metabolism and sporulation in Streptomyces venezuelae ISP5230 by jadW 1, a member of the afsA family of γ-butyrolactone regulatory genes","year":2003,"lang":"en","type":"article","venue":"Microbiology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Dalhousie University","keywords":"Biology; Gene; Mutant; Gene cluster; Secondary metabolism; Streptomyces griseus; Genetics; Regulator gene; Streptomyces coelicolor; Streptomyces; Biosynthesis; Biochemistry; Regulation of gene expression; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007610647,0.0003834433,0.0001666379,0.0002205433,0.0001617909,0.0002589389,0.0001372388,0.0001055191,0.0003455697],"category_scores_gemma":[0.0001234439,0.0001262333,0.0001257041,0.0001747105,0.0001165831,0.00007913494,0.0001881645,0.0002666339,0.0001338898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003038293,"about_ca_system_score_gemma":0.0002164561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003086448,"about_ca_topic_score_gemma":0.004175523,"domain_scores_codex":[0.9999423,0.00001022216,0.000005562584,0.00001542331,0.00001300925,0.00001350946],"domain_scores_gemma":[0.9999261,0.00001312668,0.00002326455,0.000007751358,0.000006880623,0.00002292802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006404069,0.00001901529,0.001010609,0.00001299565,0.00000190772,0.00003697498,0.00001834011,0.00005063567,0.9976336,0.00002368466,0.000009278206,0.001118932],"study_design_scores_gemma":[0.00004370453,0.0005594665,0.1433717,0.00001548174,0.00003931789,0.0006849515,0.0002281729,0.003275765,0.8492642,0.0001293453,0.002367347,0.00002046414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991487,0.0001526114,0.0002379923,0.00001139328,0.000002757167,0.000005412705,0.000120413,0.00001625931,0.000304467],"genre_scores_gemma":[0.9977558,0.0001481617,0.0006461724,0.000008692289,0.00000199595,0.00001111752,0.0006736627,0.000009802594,0.0007445943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003086448,"threshold_uncertainty_score":0.006136954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005734887423393735,"score_gpt":0.2040254175445143,"score_spread":0.1982905301211206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}