{"id":"W2152651890","doi":"10.1099/mic.0.26209-0","title":"Control of growth, secondary metabolism and sporulation in Streptomyces venezuelae ISP5230 by jadW 1, a member of the afsA family of γ-butyrolactone regulatory genes","year":2003,"lang":"en","type":"article","venue":"Microbiology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Dalhousie University","keywords":"Biology; Gene; Mutant; Gene cluster; Secondary metabolism; Streptomyces griseus; Genetics; Regulator gene; Streptomyces coelicolor; Streptomyces; Biosynthesis; Biochemistry; Regulation of gene expression; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030215,0.0001365666,0.0005690565,0.00009422971,0.00001886323,0.000001461143,0.00008039443,0.0001909924,0.00009786903],"category_scores_gemma":[0.0001100301,0.00008767228,0.00008981847,0.0001606518,0.000335618,0.00003649864,0.00002861803,0.000138325,5.90045e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001402942,"about_ca_system_score_gemma":0.00007794746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001681537,"about_ca_topic_score_gemma":0.00002952907,"domain_scores_codex":[0.9989186,0.0001822842,0.0004657877,0.0002271174,0.00004687257,0.0001593746],"domain_scores_gemma":[0.9992359,0.00007842845,0.000295438,0.0002301938,0.0001346533,0.00002541333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001896357,0.00008429744,0.01852149,0.0001411888,0.00008635051,6.806341e-7,0.00008894035,9.180246e-7,0.9793209,0.0002559724,0.0004638153,0.0008458589],"study_design_scores_gemma":[0.001415969,0.00006063113,0.09442126,0.0000543832,0.0001024149,0.00003191913,0.00006498443,0.000001209542,0.8989693,0.00005503719,0.004748231,0.00007466524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837386,0.01524967,0.000003359586,0.0002620706,0.0001251294,0.0003125828,0.0001830936,0.000004293705,0.000121212],"genre_scores_gemma":[0.9992897,0.0002105306,0.0001439453,0.0001909874,0.00002124897,8.298708e-7,0.00002090972,0.00001004773,0.0001118118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08035156,"threshold_uncertainty_score":0.3575172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005734887423393735,"score_gpt":0.2040254175445143,"score_spread":0.1982905301211206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}