{"id":"W2152656428","doi":"10.1128/jvi.02798-06","title":"Human Immunodeficiency Virus Type 1 Protease Cleaves Procaspase 8 In Vivo","year":2007,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Burroughs Wellcome Fund","keywords":"Biology; Apoptosis; Protease; Virology; Programmed cell death; Caspase; Virus; CD8; Bystander effect; Immunology; Immune system; Enzyme; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009458096,0.0001226748,0.0002957234,0.000371018,0.000103331,0.000006774453,0.0002230161,0.000195893,0.000923111],"category_scores_gemma":[0.0001517739,0.00009201557,0.00008274475,0.0001811247,0.0002130984,0.00008384504,0.00004934371,0.0005451269,0.0003569828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008308661,"about_ca_system_score_gemma":0.000125487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001218323,"about_ca_topic_score_gemma":0.0001591838,"domain_scores_codex":[0.9986312,0.0001914554,0.000512804,0.0001346288,0.0000561194,0.0004738394],"domain_scores_gemma":[0.9993706,0.00008184776,0.0002299744,0.0001558537,0.0001143572,0.00004732653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001023999,0.000862875,0.01148602,0.000008310323,0.00009759559,0.0007777556,0.0003160386,0.000006456916,0.9811376,0.0002267574,0.001209845,0.002846762],"study_design_scores_gemma":[0.01058872,0.01259743,0.2327089,0.00007066553,0.00008062832,0.002701717,0.000559621,0.000001702476,0.6773242,0.00105345,0.06195629,0.0003566125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945266,0.003411559,0.00005213036,0.0001996037,0.0002582912,0.0001933926,0.000009263134,0.000008499793,0.00134064],"genre_scores_gemma":[0.999016,0.00006357609,0.00007737723,0.0001025202,0.00003298881,0.000003620035,0.000005002036,0.000009880453,0.0006889844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3038133,"threshold_uncertainty_score":0.9999902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01863338185155253,"score_gpt":0.3093104179081768,"score_spread":0.2906770360566243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}