{"id":"W2152695501","doi":"10.3389/fncel.2015.00055","title":"Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromes","year":2015,"lang":"en","type":"review","venue":"Frontiers in Cellular Neuroscience","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Toronto; Canada Research Chairs","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Institutes of Health; Rett Syndrome Research Trust; International Rett Syndrome Foundation; National Natural Science Foundation of China; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"Rett syndrome; Autism; Fragile X syndrome; Medicine; Clinical trial; Fragile x; Neuroscience; Bioinformatics; Psychiatry; Psychology; Pathology; Genetics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003190983,0.0007244812,0.001108776,0.001745268,0.0002211162,0.0005911472,0.0006883764,0.0009355815,0.002227388],"category_scores_gemma":[0.0003742854,0.0001695067,0.0004751056,0.0009516063,0.0003261564,0.0006443104,0.0005159043,0.001402949,0.001504839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004693996,"about_ca_system_score_gemma":0.0005160646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006738228,"about_ca_topic_score_gemma":0.001486264,"domain_scores_codex":[0.999876,0.00002037187,0.00001819729,0.00002519071,0.00004704306,0.00001302352],"domain_scores_gemma":[0.999892,0.00004783124,0.00001740816,0.000003790121,0.00002674093,0.00001226392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007100273,0.00009808859,0.0001208514,0.01224313,0.00009832629,0.000372997,0.00005441643,0.0003058664,0.005122294,0.003971684,0.02146949,0.9560717],"study_design_scores_gemma":[0.00003588992,0.0001759609,0.001066989,0.003239953,0.0001550473,0.003355381,0.0000570643,0.0001523977,0.002227675,0.002648382,0.9868596,0.00002564125],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002616488,0.9976666,0.0002738789,0.0002462034,0.0001636677,0.000008315794,0.00002780578,0.00001393267,0.001338031],"genre_scores_gemma":[0.001287947,0.9971771,0.0003979201,0.000210004,0.0001025098,0.00001312555,0.00004033946,0.000002529817,0.0007684909],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002227388,"threshold_uncertainty_score":0.007451355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03213982342362511,"score_gpt":0.2896996394437384,"score_spread":0.2575598160201133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}