{"id":"W2152713204","doi":"10.1158/0008-5472.can-06-1199","title":"<i>In vitro</i> and <i>In vivo</i> Activity of SKI-606, a Novel Src-Abl Inhibitor, against Imatinib-Resistant Bcr-Abl+ Neoplastic Cells","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":371,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Imatinib; Chronic myelogenous leukemia; ABL; Cancer research; Imatinib mesylate; In vivo; Leukemia; Biology; breakpoint cluster region; Pharmacology; Receptor; Immunology; Tyrosine kinase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008034477,0.000288206,0.0006810852,0.0005020916,0.00008256869,0.0000384256,0.0001752945,0.0001868868,0.0001424036],"category_scores_gemma":[0.0001439716,0.0002655186,0.00008533669,0.0009940566,0.0003711502,0.0001760843,0.0001830815,0.0007724139,0.00001791721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00255734,"about_ca_system_score_gemma":0.001570095,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00994586,"about_ca_topic_score_gemma":0.002380141,"domain_scores_codex":[0.9967005,0.0001624338,0.0005227629,0.0006714004,0.0009914949,0.0009514545],"domain_scores_gemma":[0.9983295,0.0006167807,0.0001210405,0.0005239471,0.0001891241,0.0002196344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002560541,0.0008101166,0.001845284,0.0006495215,0.00003452117,0.0002420226,0.0001830552,0.0001226496,0.9893593,0.00002715852,0.003058886,0.00110693],"study_design_scores_gemma":[0.01038718,0.0002417967,0.00506246,0.0007959876,0.00002847448,0.00001274174,0.00008274164,0.000744498,0.977771,0.0000513255,0.004600184,0.0002215881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924586,0.001394446,0.00001627333,0.0005567924,0.0001550344,0.001075379,0.0002232944,0.00002302765,0.004097114],"genre_scores_gemma":[0.9963371,0.0004123765,0.0003581838,0.000107055,0.0002434453,0.0002473629,0.00001311338,0.00005829627,0.002223073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01158829,"threshold_uncertainty_score":0.9999797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02715129866584341,"score_gpt":0.3319171761275068,"score_spread":0.3047658774616633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}