{"id":"W2152713204","doi":"10.1158/0008-5472.can-06-1199","title":"In vitro and In vivo Activity of SKI-606, a Novel Src-Abl Inhibitor, against Imatinib-Resistant Bcr-Abl+ Neoplastic Cells","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":371,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Imatinib; Chronic myelogenous leukemia; ABL; Cancer research; Imatinib mesylate; In vivo; Leukemia; Biology; breakpoint cluster region; Pharmacology; Receptor; Immunology; Tyrosine kinase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002807337,0.0004117415,0.0004700908,0.0002404337,0.0001173851,0.0003304216,0.0001987707,0.0002557434,0.001425533],"category_scores_gemma":[0.0001718754,0.0001577801,0.0003167366,0.0001872526,0.0001806272,0.0001954627,0.0001216215,0.0006437034,0.0005139822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002314687,"about_ca_system_score_gemma":0.0001724295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006998559,"about_ca_topic_score_gemma":0.0008343712,"domain_scores_codex":[0.9998091,0.00006419839,0.00001997159,0.00002572624,0.00003884242,0.00004211627],"domain_scores_gemma":[0.9998112,0.00004957109,0.00005236335,0.00002661025,0.00001866079,0.0000415654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005930585,0.0002093503,0.0003528132,0.00008321609,0.00002054969,0.00002690264,0.00001687364,0.0002351184,0.9948434,0.00008183333,0.000218533,0.003318338],"study_design_scores_gemma":[0.00005130077,0.002471517,0.002803725,0.000005174833,0.00003479396,0.000210805,0.000008695206,0.0005990002,0.9923239,0.00002003042,0.001466944,0.000004037092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888337,0.005308024,0.001569232,0.0001661407,0.00005057186,0.00003367971,0.0007792917,0.0001067293,0.003152654],"genre_scores_gemma":[0.991768,0.003061724,0.001489736,0.00008512075,0.0000355883,0.00003989229,0.001846887,0.00003308133,0.001639953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001425533,"threshold_uncertainty_score":0.004768908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02715129866584341,"score_gpt":0.3319171761275068,"score_spread":0.3047658774616633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}