{"id":"W2152736079","doi":"10.1111/cge.12011","title":"Absence of <i><scp>PMS2</scp></i> mutations in colon‐<scp>CFR</scp> participants whose colorectal cancers demonstrate unexplained loss of <scp>MLH1</scp> expression","year":2012,"lang":"en","type":"letter","venue":"Clinical Genetics","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Cancer Institute","keywords":"PMS2; Colorectal cancer; MLH1; Population; Medicine; Lynch syndrome; Family medicine; Gerontology; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006345239,0.0005141292,0.0005911709,0.0004747907,0.001534294,0.000951023,0.0006340327,0.01058893,0.003166178],"category_scores_gemma":[0.007256918,0.0003416188,0.0004566579,0.0005045081,0.0008484954,0.000712072,0.0003485582,0.004913342,0.001612049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001269398,"about_ca_system_score_gemma":0.0007926675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005643412,"about_ca_topic_score_gemma":0.008652844,"domain_scores_codex":[0.9994306,0.0001674366,0.00008136166,0.00009338505,0.0001154109,0.0001117471],"domain_scores_gemma":[0.9980398,0.001069191,0.000188167,0.00008508546,0.0002860344,0.0003317234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0008150192,0.0002789166,0.09311799,0.0002023346,0.0001175033,0.1883824,0.0009435738,0.0003597862,0.005063152,0.003394183,0.6662165,0.04110857],"study_design_scores_gemma":[0.0007329133,0.0009616092,0.1535438,0.000636569,0.0005167503,0.337733,0.002462186,0.004853262,0.004840602,0.01019399,0.4832867,0.0002386665],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.0608946,0.001808609,0.0003625432,0.9017502,0.01179315,0.00004047355,0.0004776093,0.0001159565,0.02275679],"genre_scores_gemma":[0.4242242,0.00294001,0.001415026,0.5016795,0.0368245,0.00008948171,0.0003935296,0.00009922837,0.03233458],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01058893,"threshold_uncertainty_score":0.01122117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06761275212931356,"score_gpt":0.3551795487567211,"score_spread":0.2875667966274075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}