{"id":"W2152770850","doi":"10.1158/1078-0432.ccr-07-1216","title":"TACE/ADAM-17: A Component of the Epidermal Growth Factor Receptor Axis and a Promising Therapeutic Target in Colorectal Cancer","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Amphiregulin; Epidermal growth factor receptor; Ectodomain; Cancer research; Epidermal growth factor; TGF alpha; Tyrosine kinase; Receptor tyrosine kinase; Growth factor receptor; EGFR inhibitors; Transforming growth factor; Biology; Chemistry; Kinase; Signal transduction; Cell biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001646355,0.0003295153,0.0003688709,0.0002406807,0.000137414,0.0003938685,0.0001791253,0.0002553962,0.0009379355],"category_scores_gemma":[0.00008954637,0.0000973979,0.0001549447,0.0002005608,0.0002448763,0.0002619824,0.0001690522,0.0005696735,0.0002912123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003298397,"about_ca_system_score_gemma":0.0002598528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002537104,"about_ca_topic_score_gemma":0.0005967293,"domain_scores_codex":[0.9999171,0.0000156618,0.000005393414,0.00001156058,0.00002638034,0.00002394045],"domain_scores_gemma":[0.999933,0.000007792607,0.0000207449,0.000004627934,0.00001316757,0.00002066286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004141531,0.00009630376,0.001512463,0.0002489071,0.00002121874,0.0003547333,0.00002226064,0.0001993653,0.975445,0.0002194454,0.0002672654,0.02119881],"study_design_scores_gemma":[0.0001439093,0.002115062,0.01461199,0.00002971641,0.0001109922,0.004743411,0.00007846302,0.001743328,0.9568198,0.0001806241,0.01941324,0.000009383698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9392438,0.05095855,0.005060231,0.0008905658,0.00009886436,0.00009452561,0.0002796207,0.0001967749,0.003177119],"genre_scores_gemma":[0.9806157,0.01234528,0.003789343,0.0001693747,0.00006675187,0.00004390639,0.0004246298,0.00001503642,0.002530007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009379355,"threshold_uncertainty_score":0.003137708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3092313405282823,"score_gpt":0.5201451766951082,"score_spread":0.2109138361668259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}