{"id":"W2152774786","doi":"10.1373/clinchem.2012.198739","title":"The Long and Winding Road to FDA Approval of a Novel Prostate Cancer Test: Our Story","year":2012,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Prostate cancer; Test (biology); Medicine; Drug approval; Cancer; Internal medicine; Pharmacology; Biology; Drug","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000727104,0.0001058909,0.0002373709,0.0000102814,0.00009314699,0.00001154898,0.00008634181,0.0000988016,0.00001147019],"category_scores_gemma":[0.0007872199,0.00006446148,0.00007426378,0.0000963504,0.0001547712,0.00003966365,0.0001045532,0.0003671759,0.000004284548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007159747,"about_ca_system_score_gemma":0.0001927164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001152792,"about_ca_topic_score_gemma":0.000001719051,"domain_scores_codex":[0.9989599,0.00001533714,0.0002761278,0.0001989222,0.0002113801,0.000338339],"domain_scores_gemma":[0.9989733,0.0002692669,0.0000816389,0.0002328149,0.00008631405,0.0003566497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004451401,0.0004544706,0.9400611,0.0003048505,0.0001063624,0.000007146387,0.0002085975,4.233098e-7,0.0237974,0.000001936468,0.00230784,0.03230472],"study_design_scores_gemma":[0.008822407,0.0005005811,0.8004956,0.0007893912,0.0002756676,0.0000581719,0.00215586,0.0001233609,0.1646873,0.000008527769,0.02171366,0.0003694525],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909388,0.003477769,0.00000389343,0.004210641,0.0001138045,0.0003116232,0.00002289384,0.00001655893,0.0009040565],"genre_scores_gemma":[0.9879165,0.0005877116,0.0001205643,0.0001074625,0.0006130844,0.00006157708,0.000007098264,0.00001610795,0.01056988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1408899,"threshold_uncertainty_score":0.2628663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09264885022634976,"score_gpt":0.4434040720497111,"score_spread":0.3507552218233613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}