{"id":"W2152783885","doi":"10.1016/j.jmb.2010.06.044","title":"Structural Characterization of the Rod cGMP Phosphodiesterase 6","year":2010,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Eye Institute; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Foundation Fighting Blindness","keywords":"Visual phototransduction; Phosphodiesterase; Protein subunit; Biophysics; Chemistry; Biochemistry; Crystallography; Biology; Stereochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001703889,0.0001013625,0.0001497864,0.00004241935,0.00004784536,0.000008295885,0.0002047559,0.0001658368,0.00002958384],"category_scores_gemma":[0.0001177055,0.00006429746,0.0001640566,0.00007551481,0.0001358808,0.000005564869,0.00006623819,0.0001687621,7.828774e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005436757,"about_ca_system_score_gemma":0.00007664204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002562963,"about_ca_topic_score_gemma":0.00000562454,"domain_scores_codex":[0.999266,0.00008653729,0.0003354903,0.0001102112,0.00009173153,0.0001100312],"domain_scores_gemma":[0.9990117,0.000006646906,0.0004667918,0.0002360704,0.0002337103,0.00004508777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000100147,0.0000180238,0.007142185,0.000005253798,0.00004439032,0.000001468028,0.00002347861,0.00001785119,0.9902391,0.0002644615,0.00003587832,0.0021078],"study_design_scores_gemma":[0.0004714857,0.0002060497,0.03609693,0.000008705275,0.00002285371,0.0001511947,0.000008053548,0.00002943466,0.9574559,0.0002125719,0.005261245,0.00007551663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950567,0.0001170627,0.002727851,0.0003562886,0.001593114,0.00007550255,0.00001011725,0.000001953436,0.00006144746],"genre_scores_gemma":[0.9990032,0.00002698387,0.0003289153,0.0003241154,0.0001842841,0.000001126725,0.00003234011,0.000009862064,0.00008918906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0327831,"threshold_uncertainty_score":0.2621974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004406899945037366,"score_gpt":0.2362360773369156,"score_spread":0.2318291773918782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}